DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and nep-3

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_494679.2	Gene:	nep-3 / 173730	WormBaseID:	WBGene00016778	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	168/743 - (22%)
Similarity:	285/743 - (38%)	Gaps:	173/743 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SHVLSVLVLAAP-------------------TSEDVLNQDT----PYMKELMRQAKAA----EIE 49
            |.|..:::||.|                   .||:..|..|    |..|.:....:..    ::.
Worm    11 SFVTVIIILAVPIIVILPLVLLLEAGKIGGEVSENCSNHSTSSASPKPKPMCLTPECITLVHQLL 75

  Fly    50 SFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPED 114
            :|.:..||||::||..:||.|...|.....|   |...:.:.|.|.|..|.    .:.|..:..:
Worm    76 NFQDPSVDPCENFYQAACGKYNEHNVIDGSR---TAQKQQIVKRLIRDFLH----KNQSSTSKSE 133

  Fly   115 IQVKHFYESCLQIKEL----NSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYG 175
            ..:|..||.|.:.|.:    |....:::...|.:.|:.|:|: .:|....|: ||..
Worm   134 NSMKLLYEKCKEAKTIKVLGNQNLLQEIFMNIQKIGSWPVLD-ENWDGKKFN-LNEM-------- 188

  Fly   176 IMSIIGVGVATDFANNQKNIIYINQQEF-PLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKD 239
            ::|:|.:|| ::|...:   |.|:...| .:|....:...|          |:..|:.|
Worm   189 LLSLIRLGV-SNFGFFE---IIISSDAFVEIKPARNFPTRE----------NLSDIISK------ 233

  Fly   240 ELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAE--LRERYAPTLDTDQLIFVSMGEK 302
                          |.|.:|...|            :|..|  |||
Worm   234 --------------VFLGNGFQPN------------ITAIENDLRE------------------- 253

  Fly   303 ISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEACVDFTKTYFAK 367
                 ||..:|..::|..:|:.||..::.|||....:...:.:   ....|.|.|......:..:
Worm   254 -----YENLQRELKSLERLIQTTPNRSLVNYLIFNYLKSVMLE---YKRLPEEQCEGVVIDFLPR 310

  Fly   368 NLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVNNY 432
            ....:..:.:.::::.:.:..|...:|..|.:.:..|   .|:...::.:|:.|::.:...:.
Worm   311 ASTRVFVQNFLDKENRKYVAGMIEDVKMGFIDMIQES---TWLNEESKKVAVQKVKNIKSMIG-- 370

  Fly   433 VKENFTE-------EFADLNLQNTDCVENL-RQVQMLQAKQMRQLYH-----QPAKP-LEAGELL 483
             ..:|.|       .|.|||::.||....: |::|....:|..:...     .|.:| |.|...
Worm   371 -YPDFFEPPGTLDRSFKDLNIEQTDSYHTIVRKIQKFTNEQCMEFVASEIPLDPRQPILHANAF- 433

  Fly   484 SYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSK 548
             |..:|.|   :|..|| |..|  |:...:|..|....:..::.||:.|.||.:|..:|:.|..:
Worm   434 -YQNTNFL---AILAPV-LDDP--IFDTTFPRYVNLAVIGNVLAHEIGHAFDHTGINYDDAGQQR 491

  Fly   549 DWWDEKSSSNFLKRRDCFTKQYGRYVYD----GIQLKESTAQSENIADNGGMRLAYTAYRKWYEN 609
            .|...:.|..:.||..|..:|:..  ||    |..|..|....|..||..|:..|:..::|
Worm   492 IWLTPEDSEEYGKRLRCLLRQHDE--YDDPDFGRNLNGSKTLHEISADRFGVEAAWRTFKK---- 550

  Fly   610 QLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWC--NDVHPKVKALQVSTDDHMPGKFRVIGT 672
             |.|.|     ..|.:....:...||:|.:.|..||  .|......|||   .:|....|||.|.
Worm   551 -LDLSN-----ESEIVGFQNFNIDQLYFRTAALIWCRQRDTTDLQYALQ---REHPTNNFRVNGI 606

  Fly   673 LSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            .:|..:|::.|||..||.|||.:||.|:
Worm   607 YANMPQFAETFNCPLGSPMNPKKKCDLF 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	151/667 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	153/667 (23%)
nep-3	NP_494679.2	M13	82..631	CDD:189000	153/667 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920