DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and nep-11

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	196/778 - (25%)
Similarity:	336/778 - (43%)	Gaps:	160/778 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LVLAAPTS---EDVLNQDTPYMKELMRQ----AKAAEIESFMNQKVDPCKDFYAFSCGN------ 69
            :|..||||   |...:.:.|...|:...    ..|....:.||..||||.||:.|:||.
Worm   136 IVPEAPTSPEPEVTTSTEKPKEPEVCSTPGCVRAATHFLNAMNTSVDPCDDFFEFACGQWNDQHP 200

  Fly    70 ------------YKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYE 122
                        |.|......:|||......|.::.:|                    ..:..|.
Worm   201 IPDDMYGFGTFAYAREQVRQQLRVLLEQEVVTESESIN--------------------MARATYR 245

  Fly   123 SCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATD 187
            ||:...:|:...:..|...:.|.|..|||: .:|.:..|::.:........||:.....:.:..|
Worm   246 SCMNKTQLDELMTGPLFETLTELGEWPLLQ-ENWDKTKFNFTSLLVNSRRDYGVDVFFQLYIYAD 309

  Fly   188 FANNQKNIIYINQQEFPL--KTRSMYMD-----NETAIYRQNYQNNIQLILEKYLGVKDELARKA 245
            ..|..:|.::|:|....|  .||..|::     :....||: |...|..:|:    ....|.|..
Worm   310 SKNTSRNTLFIDQSTLALGRGTRDYYLNTTLFSSHMTAYRK-YLRQIAHLLK----TDGNLTRSE 369

  Fly   246 A------KEMFEFEVDLAHGLVDNNKHLN---------LRDLIELLTVAELRERYAPTLDTDQLI 295
            :      :::.:||::||..:|..::..|         ::||..||          |.:|
Worm   370 SEMNADIEKIIDFEIELAKIIVAEDERRNNTRLYNKRQIQDLYNLL----------PQVD----- 419

  Fly   296 FVSMGEKI--SDKVYEYNR---------RYQQNLVEVIERTPKSTVANYLFLRLI---------- 339
            :|...:.|  ||..:.::.         .|.|::.|:||:|....:.||:..|::
Worm   420 WVPFFQSIAPSDLTHLFHNETEIIICEIEYLQHVSELIEKTDVGLLTNYVLWRVVQSNVRYLDER 484

  Fly   340 -----WEFIQKPSGVAEKPT--EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTF 397
                 .:|::..:|..:.|.  :.|.....|........:..:.:..|....|...|...|:::|
Worm   485 FEDIKQDFLKVMTGQQQSPPRWKDCAQVPSTVLPLAAGAIYVQAHFQESDKHEALRMIMHLRNSF 549

  Fly   398 KETLLSSPALDWIEPSTRSLAIAKLEAMTLEVNNYVKENFT-------EEFADLNLQNTDCVENL 455
            .:.:..:   ||::..|:::||.|..:|   :||....:.|       :::..|::.::|....:
Worm   550 ADLVRQN---DWMDEETKAVAIEKANSM---INNIGYPDVTNDLPKLDKQYLGLSISDSDTYYYI 608

  Fly   456 --RQVQMLQAKQMRQLYHQPAKPLEAGEL--------LSYTPSNILLENSIKVPVALLQPFYIWS 510
              :.|..:|:::.::|    .||.:..|.        ..|:|.    :|:|..|..:|||.: :|
Worm   609 MKKSVVWMQSREFQKL----TKPFDKHEFDISPAVVNAFYSPE----KNAITFPAGILQPPF-FS 664

  Fly   511 DVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVY 575
            ..:|.||.:|.:..:||||:.|||||.|.::|:.||..:||.|.|.::|..||.|..:|||.|..
Worm   665 GTFPKAVNYGAIGAVIGHEITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTV 729

  Fly   576 --DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNL-RYTAKQLFF 637
              ...::.....|.||||||||::.|:.||:|:     ...||.:    ..||.| :||.:|:||
Worm   730 PKTNFRVNGKLTQGENIADNGGVKEAFQAYQKY-----VTENGEE----PRLPGLQQYTNEQIFF 785

  Fly   638 ISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            :|:|..||..........||.||:|.|..|||||.|||.:.|:..:.|...:.:||..|||::
Worm   786 VSYAHFWCGKKKEAAAMQQVLTDEHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	182/728 (25%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	182/728 (25%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	187/738 (25%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	182/728 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020