DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and nep-13

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001342017.1	Gene:	nep-13 / 173672	WormBaseID:	WBGene00018196	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	747	Identity:	165/747 - (22%)
Similarity:	318/747 - (42%)	Gaps:	111/747 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LFCIWIASHVLSVLVL-----AAPTSEDVLNQDTPYMKELMRQAKAAEIES----FMNQKVDPCK 60
            :.|:.|.:..:..:::     :||  :.:...|....:::.:.|:...:.|    :.|..:|||:
Worm    46 IICLVIIAICMGAVIVFWRMDSAP--QAICKTDHNKTRDVCKTAECITLSSTLLNWQNTNIDPCE 108

  Fly    61 DFYAFSCGNYKR--INSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYES 123
            |||.:|||.|:.  :|..:......|.|.    |.:.:.:||..:|..:|.:.     :...||.
Worm   109 DFYEYSCGRYQEHTLNDGIRANEKDTIVM----KLIRQFVLKNQSTTSNSENA-----LMLLYEK 164

  Fly   124 CLQIKELNSTY--SEKLKRLIAE----FGTMPLLEGSSWQEDDFDWLNTTARMA--HR--YGIMS 178
            |.....:.:.:  :|.::|.:.|    .|:.|:.: .:|....|:..|..:.||  |.  :|:..
Worm   165 CSLRYRMENRHQETEVIQREVFENIRKIGSWPIAD-KNWNSSHFNLNNMLSNMASIHMLPFGLFE 228

  Fly   179 IIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELAR 243
            ...:.:.......::.:|...:.:|.:....:.    .||......|.|..|::|   ||:::|
Worm   229 TRVIELYPMNTTAKQLVIRPTKLKFSIPQEELV----RAIRDLLSVNGITSIMKK---VKEDVA- 285

  Fly   244 KAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLI----------FVS 298
                |.|..:.::      .|.|::.:.  :..|::|| ::..|.:|.:::|          :.|
Worm   286 ----ESFALDKEI------GNIHIDPQP--KPATLSEL-QKAVPDIDFERIIKSYLNPKTGNWSS 337

  Fly   299 MGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLI----WEFIQKPSGVAEKPTEACVD 359
            :..||....:|.......||..:|.||....:||||||:.|    :.|.......::  .:.|.:
Worm   338 LRTKIFSARFELFFGKNNNLSSIIARTKPRILANYLFLKYIEYAYFFFFDNTKVFSD--DDFCTE 400

  Fly   360 FTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEA 424
            ...|...:....:..|.:..:::......:...:|:.:.|.:.:|   .|:..|||..||.|:..
Worm   401 VVTTSLPRASLRVFVRNHFKKENMAVASEIVEVVKTAYVEIINNS---TWLHNSTRESAIEKVVK 462

  Fly   425 MTLEVNNYVKE-----NFTEEFADLNLQNTDC-------VENLRQVQMLQAKQMRQLYHQPAKPL 477
            |. :|..|.:|     ...|.|..|.|..:|.       |...:..|::.......|.: |.:||
Worm   463 MK-KVIGYTEEYERTGALDEMFETLQLSRSDSFFVLMTKVNRFKIEQLMDFVSSDSLLN-PIEPL 525

  Fly   478 EAGELLSYTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFD 542
            .......:...|:|   ::.||. |.:|.:.:.  ||..|....:..::.||:.|.||.:||:.|
Worm   526 VMANAFYFPTKNLL---NVLVPF-LDKPLFDFK--YPRYVAMAGVGRVLAHEIGHAFDINGRQTD 584

  Fly   543 EKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQ--SENIADNGGMRLAYTAYRK 605
            |.|.::|||..:.:..:.:|.:||.:|:..:.....:.|::..:  :|.|||..||..::.|::|
Worm   585 EIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSFKGKQNGTEVLAEIIADALGMEASWIAFKK 649

  Fly   606 --WYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFR 668
              ..|.|..:.....|..|            |:|...|..:|  ...:::........|...|||
Worm   650 INLTEEQGLIQFEDHDFGK------------LYFQVAALDFC--APSRIEERYSDQLSHPTNKFR 700

  Fly   669 VIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            :.|..||...|:..:.|..||.|||:::|.::
Worm   701 INGAFSNSRAFADTYKCPVGSKMNPVQRCDMF 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	155/686 (23%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	156/682 (23%)
nep-13	NP_001342017.1	M13	104..729	CDD:189000	156/682 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920