DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	720	Identity:	198/720 - (27%)
Similarity:	337/720 - (46%)	Gaps:	98/720 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKI 98
            |..|...|.|:.  :.:.::..:|||:|||:|:||.:.| ..|:....||.|....:.:....::
Mouse   101 PERKAFARAARF--LSANLDASIDPCQDFYSFACGGWLR-RHAIPDDKLTYGTIAAIGEQNEERL 162

  Fly    99 LKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLE----------- 152
            .::|..|..........:|:.|:.|||.::|:     |:|       |..|:||
Mouse   163 RRLLARPTGGPGGAAQRKVRAFFRSCLDMREI-----ERL-------GPRPMLEVIEDCGGWDLG 215

  Fly   153 GSSWQEDDFDW-LNTTARMAHR----YGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYM 212
            |::.:.....| ||   |:.::    |...::..:.|:.|..|:.:.:|.|:|....|..|::|:
Mouse   216 GAADRPGAARWDLN---RLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYL 277

  Fly   213 --DNET----AIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRD 271
              |.|:    |.||...|..::|     ||. |.:.:| |:|:.:.|..||:..|.....|. ||
Mouse   278 AQDEESEKILAAYRVFMQRLLRL-----LGA-DAVEQK-AQEILQLEQRLANISVSEYDDLR-RD 334

  Fly   272 L---IELLTVAELRERYAPTLD----TDQLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKST 329
            :   ...:|:.:| ::..|.|.    .||:......|:  ::|......|.|.:.::|..||:..
Mouse   335 VSSAYNKVTLGQL-QKIIPHLQWKWLLDQIFQEDFSEE--EEVVLLATDYMQQVSQLIRSTPRRI 396

  Fly   330 VANYLFLRLI---WEFIQKPSGVA-----------EKPTE---ACVDFTKTYFAKNLDNMIYRRY 377
            :.|||..|::   .|.:..|...|           :||.|   .|:.....:|...|..:....:
Mouse   397 LHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEH 461

  Fly   378 KNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEV---NNYVKENFTE 439
            .:..|..::..:...:|....:.|   ..|||::..|::.|.|||:.|.:.|   :..:|....:
Mouse   462 FSAASKAKVQQLVEDIKYILGQRL---EELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVD 523

  Fly   440 EFADLNLQNTDCVEN----LRQVQMLQAKQMRQLYHQPAKPLEAGELLSYTPSNILLENSIKVPV 500
            :..:..:......:|    :|....|..|::||...:.:..|....|.:|...|   :|.:..|.
Mouse   524 KEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSSWLLPPQALNAYYLPN---KNQMVFPA 585

  Fly   501 ALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDC 565
            .:||| .::...:|.::.:|.:..:|||||.||:||.|.::|..||...||.|.|.|:||::.:|
Mouse   586 GILQP-TLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAEC 649

  Fly   566 FTKQYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRY 630
            ..:.|..:.....::.......|||||.||::|||.||:||...     :|.:    ..|..|:|
Mouse   650 IVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVRE-----HGPE----HPLHRLKY 705

  Fly   631 TAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIE 695
            |..|||||:|||:||.....:...|||.||.|.|..:||:|::|.||||.:.|:|...|.|||:.
Mouse   706 THNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVH 770

  Fly   696 KCILY 700
            ||.::
Mouse   771 KCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	189/693 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	192/693 (28%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	193/694 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840