DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and Gm49333

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	711	Identity:	211/711 - (29%)
Similarity:	336/711 - (47%)	Gaps:	109/711 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHD 107
            |.:|...:::.|.||:|||.||||.:.|.|...|.| .....|.:|. ..|:.|||.|  ||..:
Mouse   248 AGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGR-SRWNTFNSLW-DQNQAILKHLLENTTFN 310

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTA 168
            |....|. :.:.||.||||.:.:....::.|:.||.:.|    |.|      |.||.|  ::...
Mouse   311 SSSEAER-KTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWNITGP------WDEDSF--MDVLK 366

  Fly   169 RMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEK 233
            .:|..|.......|.|:.|..::..|||.::|....|.:|..|: |.||         .:.:|..
Mouse   367 AVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYL-NRTA---------NEKVLTA 421

  Fly   234 YLGVKDEL----------ARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPT 288
            ||....||          .|:..:::.|.|:.||:..|..::..:...:...::::|| :..||.
Mouse   422 YLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISEL-QALAPA 485

  Fly   289 LDTDQLIFVS-------MGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKP 346
            :  |.|.|:|       :|:  |:.|..|...|.|.:.|:|.||..|.:.||    |||..:||.
Mouse   486 V--DWLEFLSFLLSPLELGD--SEPVVVYGTEYLQQVSELINRTEPSILNNY----LIWNLVQKT 542

  Fly   347 SGVAEKPTE---------------ACVDFTKTYFAKNLDNM------IYRRYKNEKSSREI-DSM 389
            :...::..|               :|....:|..:...|.:      ::.:...::.|:|| :.|
Mouse   543 TSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGM 607

  Fly   390 WHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNNYVKENFTEEFADL----NLQN 448
            .::::|.|:|||   ..|.|::..||..|..|.:|:  .:...:::.|  .:|..|:    .:..
Mouse   608 INEIRSAFEETL---GDLVWMDEKTRLAAKEKADAIYDMIGFPDFILE--PKELDDVYDGYEVSE 667

  Fly   449 TDCVENLRQVQMLQAKQMR-QLYHQPAKPLEAGELLSYTPSNI-----LLENSIKVPVALLQ-PF 506
            ....:|:..:....||.|. ||...|::     :..|.||..:     ..:|.|..|..:|| ||
Mouse   668 DSFFQNMLNLYNFSAKVMADQLRKPPSR-----DQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF 727

  Fly   507 YIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYG 571
            |..:  :|.|:.||.:..::||||.|.|||.||::|::||.:.||..:|.:.|.....|..:||.
Mouse   728 YAHN--HPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYS 790

  Fly   572 RYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLF 636
            :|..:|.:|.......||||||||::.||.||:.|...     :|.:    :.||.:..|..|||
Mouse   791 QYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRK-----HGEE----QPLPAVGLTNHQLF 846

  Fly   637 FISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |:.|||.||:...|:.....:.||.|.|.:|||:|||||..:|.:.|.|..||.|||.:.|
Mouse   847 FVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	205/698 (29%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	208/698 (30%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	248..901	CDD:226118	207/703 (29%)
		M13	259..908	CDD:189000	209/700 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850