Protein Alignment Nepl20 and Ece2

DIOPT Version :10

• Sequence 1: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 711
• Identity: 211/711 - (29%)
• Similarity: 336/711 - (47%)
• Gaps: 109/711 - (15%)

  Fly    45 AAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFETLTKGLNRKILKML--NTPHD 107
            |.:|...:::.|.||:|||.||||.:.|.|...|.| .....|.:|. ..|:.|||.|  ||..:
Mouse   101 AGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGR-SRWNTFNSLW-DQNQAILKHLLENTTFN 163

  Fly   108 SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTA 168
            |....|. :.:.||.||||.:.:....::.|:.||.:.|    |.|      |.||.|  ::...
Mouse   164 SSSEAER-KTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWNITGP------WDEDSF--MDVLK 219

  Fly   169 RMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEK 233
            .:|..|.......|.|:.|..::..|||.::|....|.:|..|: |.||         .:.:|..
Mouse   220 AVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYL-NRTA---------NEKVLTA 274

  Fly   234 YLGVKDEL----------ARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPT 288
            ||....||          .|:..:::.|.|:.||:..|..::..:...:...::::|| :..||.
Mouse   275 YLDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISEL-QALAPA 338

  Fly   289 LDTDQLIFVS-------MGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKP 346
            :  |.|.|:|       :|:  |:.|..|...|.|.:.|:|.||..|.:.||    |||..:||.
Mouse   339 V--DWLEFLSFLLSPLELGD--SEPVVVYGTEYLQQVSELINRTEPSILNNY----LIWNLVQKT 395

  Fly   347 SGVAEKPTE---------------ACVDFTKTYFAKNLDNM------IYRRYKNEKSSREI-DSM 389
            :...::..|               :|....:|..:...|.:      ::.:...::.|:|| :.|
Mouse   396 TSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGM 460

  Fly   390 WHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNNYVKENFTEEFADL----NLQN 448
            .::::|.|:|||   ..|.|::..||..|..|.:|:  .:...:::.|  .:|..|:    .:..
Mouse   461 INEIRSAFEETL---GDLVWMDEKTRLAAKEKADAIYDMIGFPDFILE--PKELDDVYDGYEVSE 520

  Fly   449 TDCVENLRQVQMLQAKQMR-QLYHQPAKPLEAGELLSYTPSNI-----LLENSIKVPVALLQ-PF 506
            ....:|:..:....||.|. ||...|::     :..|.||..:     ..:|.|..|..:|| ||
Mouse   521 DSFFQNMLNLYNFSAKVMADQLRKPPSR-----DQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF 580

  Fly   507 YIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYG 571
            |..:  :|.|:.||.:..::||||.|.|||.||::|::||.:.||..:|.:.|.....|..:||.
Mouse   581 YAHN--HPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYS 643

  Fly   572 RYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLF 636
            :|..:|.:|.......||||||||::.||.||:.|...     :|.:    :.||.:..|..|||
Mouse   644 QYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRK-----HGEE----QPLPAVGLTNHQLF 699

  Fly   637 FISFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697
            |:.|||.||:...|:.....:.||.|.|.:|||:|||||..:|.:.|.|..||.|||.:.|
Mouse   700 FVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	M13	56..697	CDD:341056	208/698 (30%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	209/700 (30%)