DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl20 and kel

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	738	Identity:	154/738 - (20%)
Similarity:	263/738 - (35%)	Gaps:	178/738 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PCKDFYAFSCG--------NYKRINSALN--MRVLTTGVFETL--TKGLNRK------------- 97
            || |::.|:||        :.:|:...:|  ..|.|.|:.|..  |.|.::.
Zfish   100 PC-DYFLFACGAGGSSTNRDRQRVKGEVNKHSEVRTRGLIEMRRGTDGWSKSDGQLKTFPDRQTA 163

  Fly    98 ----ILKMLNTPHD--SHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSW 156
                |.::|..|.:  |....|. :.|:|::||:..:......||....|:.:.|...:  ...|
Zfish   164 LLTAIKEILEAPDEAVSMGAAEQ-KAKNFFKSCMNAESREKMGSEPFLTLLQQLGGWAV--SGVW 225

  Fly   157 QEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQ----KNIIYINQQ--EFPLK--TRSMYMD 213
            .:.||:  :|.|.:..:|.......|.|..:.:..|    ::.|.|::.  :||::  :::....
Zfish   226 NQTDFN--STLALLMGQYSTFPFFNVYVGPEPSEEQSASNRHYIQIDEPHFQFPIEWNSKTQKAK 288

  Fly   214 NETAIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTV 278
            ..|...|..|....|.::  .|||..:...:...........||.........|:.:.|....|:
Zfish   289 ANTRYLRPFYSACGQYLV--LLGVPSDRTTQHCGLFVSLSTTLAVATFPLPYRLSQKLLYRRTTI 351

  Fly   279 AELRERYAPTLD-------TDQLIFVSMGEKISDKVYEYNRRYQQNLVEVI-------ERTPKST 329
            .|| :..||.:|       |.|.:.:|.    ||.|..:|..|..::.:.|       |......
Zfish   352 QEL-QTLAPAVDWLACLQATFQPLLISK----SDIVLVHNLPYIIHMSKTIHLWQVQHELMGTGP 411

  Fly   330 VANYLFLRLIWEF----------IQKPSGVAEKPTE------ACVDFTKTYFAKNLDNMIYRRYK 378
            :..|:...|:...          |.:...:|...|:      .||..|:    :..|.::....:
Zfish   412 LNTYMIFSLLQTLIPALDSRFFQIMRNYSIATGDTQEMPHWWRCVQQTE----RGFDTLLSHAIR 472

  Fly   379 NEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAM----TLEVNN--YVKENF 437
            .:.:.:|.:.:...:.|:.|:.|..   |.|.:.......:.|:.::    :...||  |.:.|.
Zfish   473 EKHAQKEAEELIQDVYSSLKKKLTD---LSWRDEKESDFILNKINSLNPRISTNTNNLSYTELNH 534

  Fly   438 TEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKPLEAG---ELLSYTPSNILLENSIKVP 499
            ..|...||  ..|...|..|:.:|:.|...:|       |..|   |.||.||  .:..|.|.||
Zfish   535 LYEKVILN--EEDFFSNYLQILLLEQKSRARL-------LSLGTQTEGLSMTP--FISGNDIIVP 588

  Fly   500 VAL-LQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRR 563
            |.: :.||:..|  ||.|:.:|||..|:..:|:|                           |...
Zfish   589 VGMFVSPFFHSS--YPRALNYGTLGSLMAKDLLH---------------------------LLLP 624

  Fly   564 DCFTKQ----------YGRYVY--------DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQ 610
            |.:||.          :..|:.        |...| .|:.|.|.......:::|..||:..::..
Zfish   625 DIYTKAKNPETESLCVWSHYLSVTKGPGWGDAFYL-PSSKQQEVWVQYSALQVALDAYKMSFKRY 688

  Fly   611 LTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCN-DVHPKVKALQVSTDDHMPGKFRVIGTLS 674
            |         ...:||...|.  .||..||.:..|: |.:.:...|:.|        |.|....|
Zfish   689 L---------ADSSLPGFSYV--HLFLSSFTKVTCDTDAYREFMPLEPS--------FLVTVLCS 734

  Fly   675 NFEEFSKEFNCHAGSAMNPIEKC 697
            |.....|...|.......|.|.|
Zfish   735 NSGLCPKPLTCMNKPQSFPAEMC 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	151/730 (21%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	153/736 (21%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	119/552 (22%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	40/178 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950