DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and mme

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	209/777 - (26%)
Similarity:	343/777 - (44%)	Gaps:	137/777 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LFCIWIASHVLSV-LVLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCG 68
            :.||::.  ::|: ::||..||.|.:......:      :.||.|.:.|:...|||.|||.::||
Frog    26 ILCIFLG--IISIAMILAYATSNDGICTSQACI------STAARIIANMDAATDPCNDFYQYACG 82

  Fly    69 NYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQ--IKELN 131
            .:.:.|...:..:: :..|:.|...: ..:||.......:.|.|...:||.||:||:.  ||.|
Frog    83 GWLKKNRIPDNNIV-SNTFDILRTDI-EVVLKDALEKESADDIPAIKKVKTFYKSCIDETIKNL- 144

  Fly   132 STYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIM-----------------SI 179
                .|...||.   |:|.|         :||.........|||::                 .:
Frog   145 ----RKGGPLIK---TLPAL---------YDWPIAVDNWETRYGLVWSAQESIAGFITKYGQSGL 193

  Fly   180 IGVGVATDFANNQKNIIYINQQEFPLKTRSMYMDNETA-----IYRQNYQNNIQLI-LEKYLGVK 238
            |.|.|:.|..|:...|::|:|....|.::..|....|:     .|.:...:...|| .|:.|.:.
Frog   194 INVYVSEDLTNSSTYILHIDQPGLGLPSKDYYDCKGTSEIACLAYMEQMVSVAMLIRKERNLTIN 258

  Fly   239 DELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLI-------- 295
            ::......:::|:.|.::|..........||.|:.:.:|::.:.:.| |....||.|
Frog   259 EDKILSEMEKVFKLEREIAKAEASEEIRENLNDIYKKMTLSGIAKTY-PLKMNDQNINWLKLINA 322

  Fly   296 FVSMG-------EKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQ------KPS 347
            .:|.|       |:::....:|.::     :..:.:.....:.|||..|.|...|.      |.:
Frog   323 IISPGGVSIEENEQVALICSDYLKK-----LRFLNKYKARELQNYLGWRYILSAINDLSLEYKNT 382

  Fly   348 GVAEKPT-----------EACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETL 401
            |:..|..           :.||    ||...|:::.|.|.|..|..|.:|:.:  ::|...||.:
Frog   383 GIHLKKALYGNAAEGSDWQTCV----TYLNDNMEDAIGRLYLKETLSADIEHV--KVKDKVKEII 441

  Fly   402 LS--------SPALDWIEPSTRSLAIAKLEAMT--LEVNNYVKENF--TEEFADLNLQNTDCVEN 454
            ..        ...:||::..|:..|..|:.::.  :..:..:.::|  .|.:::|..:..:..||
Frog   442 AEIRRAFLEMLEEMDWMDEDTKKRAARKVASINERIAFSEDIMDDFKLNEGYSELEFRVDELFEN 506

  Fly   455 LRQ-VQMLQAKQMRQLYHQPAK------PLEAGELLSYTPSNILLENSIKVPVALLQ-PFYIWSD 511
            .:: ::.:|.|...:|..|..|      |.......|.|      .|.|..|..:|| ||:  |.
Frog   507 KQKYIEFVQKKMTSRLRKQVNKNEWVPGPAHVNAFYSLT------YNEIVFPAGILQTPFF--SS 563

  Fly   512 VYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD 576
            ..|:|:.:|.:..:||||:.||||:.|..|||.||..:||...|..||.....||..|||.|.:|
Frog   564 SQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNASMMNFSNLSQCFVNQYGNYSWD 628

  Fly   577 ---GIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFI 638
               |..|...:...|||:||||:|.||.|::.:.::.      .:|   :.||.:...:.|||||
Frog   629 EAGGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSH------KED---DLLPGIDLDSDQLFFI 684

  Fly   639 SFAQSWCNDVHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCILY 700
            ||.|.||....|:..|..:.|..|.||.|||||||.|..||||.|:|...:.|||..||.|:
Frog   685 SFGQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAYMNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	192/720 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	194/720 (27%)
mme	XP_031758820.1	M13	71..744	CDD:341056	195/720 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020