DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl20 and ece1

DIOPT Version :9

Sequence 1:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_031762312.1	Gene:	ece1 / 100485607	XenbaseID:	XB-GENE-1014218	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	719	Identity:	203/719 - (28%)
Similarity:	323/719 - (44%)	Gaps:	98/719 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRINSALNMRVLTTGVFET 89
            ||..::..:..::.|.|.|             |||:|||.:|||.:.:.|...:.. ...|.|..
Frog   113 SESCISVTSSILRSLDRSA-------------DPCQDFYQYSCGGWIKGNPVPDGH-SRWGTFNE 163

  Fly    90 LTKGLNRKILKML--NTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLE 152
            |.:. |:..:|.|  |:..:::.|.|. :.:.::::|:...::....::.|:.||.:.|...:.
Frog   164 LWEH-NQATMKHLLENSTIETNSTAER-KAQRYFQACMNETKIEELGAKPLQDLIQKLGGWAIT- 225

  Fly   153 GSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQEFPLKTRSMYM---DN 214
             ..|..|:|.  .|...:...|.......|.|:.|..|:..|:|.|:|....|.:|..|:   :|
Frog   226 -GPWDRDNFQ--ETLQLVTAHYRTSPFFSVFVSADSKNSNSNVIQIDQSGLGLPSREFYLNKTEN 287

  Fly   215 ETAIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVA 279
            |..:  ..|. |..:.|...||..:...|:..:|:.:||..||:..:...|..:...:...:...
Frog   288 EKVL--TGYL-NFMIQLGVLLGGAENSTREQMQEILDFETTLANITIPQEKRRDEEQIYHKMAAG 349

  Fly   280 ELRERYAPTLDTD---QLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWE 341
            ||:: ..|.:|..   |.:|..:....|:.|..|.:.|...:..:|..|.|..:.||    ::|.
Frog   350 ELKD-LVPAVDWMPFLQTVFYPVAINESEPVVVYAKEYLVAVSGLINSTDKRILNNY----MMWN 409

  Fly   342 FIQKPSG--------VAEKPTEA--------------CVDFTKTYFAKNLDNMIYRRYKNEKSSR 384
            .::|.|.        ..||..|.              |:..|.......|..|..:....|.|..
Frog   410 LVRKASSFLDQRFQDAEEKLMEVMYGTKKTCLPRWKFCISDTDNNLGFALGAMFVKATFAENSKL 474

  Fly   385 EIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAM--TLEVNNYVKE--NFTEEFADLN 445
            :...|..::|:.|:|.|   ..|.|::..||..|..|.||:  .:...|::.:  ...:.|.|.|
Frog   475 QALKMIKEIKAAFEENL---STLTWMDDETRRAAREKAEAIYDMIGYPNFIMDPKELDKVFNDYN 536

  Fly   446 LQNTDCVENLRQVQMLQAK-QMRQLYHQPAKPLEAGELLSYTPSNI-----LLENSIKVPVALLQ 504
            :.:....||..:.....|: ...||...|:|     :..|.||..:     ..:|.|..|..:||
Frog   537 VTSDFYFENGMRFYNFSARVTADQLRKAPSK-----DQWSMTPPTVNAYYSPTKNEIVFPAGILQ 596

  Fly   505 -PFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTK 568
             |||..|.  |.|:.||.:..::||||.|.|||.||::|:.||.:.||...|...|.|:.:|.|:
Frog   597 APFYTSSS--PTALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRPWWKNASVEAFKKQTECITE 659

  Fly   569 QYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAK 633
            |||.|..:|..:.......||||||||::.||.||:.|...     |||:.:    ||:|..:..
Frog   660 QYGNYTVNGEPVNGRQTLGENIADNGGLKAAYRAYKNWVRK-----NGAEQL----LPSLGLSND 715

  Fly   634 QLFFISFAQSWCNDVHPKVKALQVS-----TDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNP 693
            ||||:.|||.||:     |:..:.|     ||.|.|.:|||||::||.:||::.|.|..||.|||
Frog   716 QLFFVGFAQVWCS-----VRTSESSHEGLITDPHSPSRFRVIGSVSNSQEFAEHFRCPPGSPMNP 775

  Fly   694 IEKC 697
            ..||
Frog   776 RNKC 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	193/686 (28%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	196/686 (29%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	199/701 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010