DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl19 and ECE2

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	769	Identity:	185/769 - (24%)
Similarity:	313/769 - (40%)	Gaps:	165/769 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LVGSGRG--HLLTGQPAIDLRIQAREQLIS-----------------QSNDSAYVQRLMRLSKSA 63
            :||..:|  .||..:..::|.:.....|::                 .|:.:...:..:|:  :.
Human    88 MVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRV--AG 150

  Fly    64 EMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQ---QRLMEQPANV 125
            ::...:.:....||:||.:|||.|.:.||..|...|...|..|    :...|   :.|:|.....
Human   151 KILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSL----WDQNQAILKHLLENTTFN 211

  Fly   126 ETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEF-DWLDTVA 189
            .:.| |..:.:.||.|||...:: |:|..:.|::::...|...:..    .|..:.| :.|..||
Human   212 SSSE-AEQKTQRFYLSCLQVERI-EELGAQPLRDLIEKIGGWNITG----PWDQDNFMEVLKAVA 270

  Fly   190 RIKRQYGFDILLLFQQSADR-------IYVGQPKQILPE--------ANRKAVAE--DIANHLER 237
            ...|...|..:.:   |||.       |.|.|....||.        ||.|.:..  |....|..
Human   271 GTYRATPFFTVYI---SADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGM 332

  Fly   238 HLGVDPKVAVTTAREITEFEQKIAAIMV--DRRVGVMSKLYTPSDADYVDVSKL---------TQ 291
            .||..|.......:::.|.|.::|.|.|  |:|.. ..|:|     ..:.:|:|         .:
Human   333 LLGGRPTSTREQMQQVLELEIQLANITVPQDQRRD-EEKIY-----HKMSISELQALAPSMDWLE 391

  Fly   292 FVETVLD-RELLANESLYQHVPDYLMKIDELVTETPPHVLANYVF-------------------N 336
            |:..:|. .||..:|.:..:..|||.::.||:..|.|.:|.||:.                   .
Human   392 FLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQE 456

  Fly   337 ELLKHFYYERAESVV--EQCVSRVRDLFGELLDHMLFEQYED-------EGTLKDIYVVWQQLQR 392
            :||:..|..:...|.  :.|:|...|..|..|..:..:...|       ||.:.:|...:::.
Human   457 KLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA-- 519

  Fly   393 SFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAEVNFTQR-----YEELHLKPRDYLHNLR 452
              .|.|.     |:..:||:...|:.:....:| |:.:.....:     |:...:....:..|:
Human   520 --LGQLV-----WMDEKTRQAAKEKADAIYDMI-GFPDFILEPKELDDVYDGYEISEDSFFQNM- 575

  Fly   453 TILNHQSLRVKV----------KTQTSVT-------YDPVGKRVLLPVALLQPNFLWSRYYPKAV 500
              ||..:...||          :.|.|:|       |.|....::.|..:||..| ::|.:|||:
Human   576 --LNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF-YARNHPKAL 637

  Fly   501 RYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPE 554
            .:|.:|.::..:|.|:.:|..:           |..:|.|.:....:|.:|||.:.::||..|..
Human   638 NFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNG 702

  Fly   555 SDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSE-SLPQLNLGSRRLFFLSFAQLWCNDANEQ 618
            .....||||||..::.||:||:..|.:     .|.| .||.:.|.:.:|||:.|||:||:
Human   703 RQTLGENIADNGGLKAAYNAYKAWLRK-----HGEEQQLPAVGLTNHQLFFVGFAQVWCS----- 757

  Fly   619 FRDKQSLFLG------TPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            .|..:|...|      :|...||||.|||.|.|.|.|.|...|.|...|.|:::
Human   758 VRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	173/690 (25%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	175/691 (25%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	175/691 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950