DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl19 and ece2b

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	721	Identity:	171/721 - (23%)
Similarity:	289/721 - (40%)	Gaps:	160/721 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 MQQDADACENFYDYSCGNWPQINPANDAYPRETNF------VQLLLKAYSHKQQRLMEQPANVET 127
            :.:.||.|::||.|:||.|.:.||..|...|.:.|      .|.:||       .|:|. ....:
Zfish   111 LDRSADPCQDFYQYACGGWVRKNPLPDGRSRWSTFNSIWDQNQAVLK-------HLLEN-GTFNS 167

  Fly   128 DEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVARIK 192
            ...|..:.:.:|.|||..::: |:|..:.|.:::...|...:.    :.|..|.|  ||.:..|.
Zfish   168 SSEAERKTQSYYLSCLNEQRI-EELGAQPLMDLITKIGGWNIT----ESWDKENF--LDVLKIIS 225

  Fly   193 RQYGFDILLLFQQSADR-------IYVGQPKQILP-------EANRKAVAE--DIANHLERHLGV 241
            ..|..........|.|.       |.|.|....||       :.|.|.:..  |....|...||.
Zfish   226 GPYRAQPFFTVSVSVDPKNSNSNVIQVDQSGLFLPSRDYYLNKTNEKVLKAYLDYMVELGLLLGG 290

  Fly   242 DPKVAVTTAREITEFEQKIAAIMV---DRRVGVMSKLY---TPSD-------ADYVDVSKLTQFV 293
            |........::|.:||..:|.|.|   :||  ...|:|   |.:|       .:::|      ::
Zfish   291 DKNSTRGQMQQILDFETALANITVPQDERR--DEEKIYHKITIADLQVLAPAIEWLD------YL 347

  Fly   294 ETVLD-RELLANESLYQHVPDYLMKIDELVTETPPHVLANYVF-------------------NEL 338
            .:||. .||...|.:..:..:|:.::.||:.:|...:|.||:.                   ::|
Zfish   348 NSVLSPLELNDTEPVVVYAKEYMQQVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFENAQDKL 412

  Fly   339 LKHFYYERAESVV--EQCVSRVRDLFGELLDHML----FEQYEDE-----------------GTL 380
            |:..|..:.....  :.|:....|..|..|..:.    |::...|                 .|:
Zfish   413 LESLYGTKKSCTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGRNVNSTV 477

  Fly   381 KDIY--VVWQ------QLQRSFRGVLQNSSANWLVPETREQLLEQ--------------LNTTSL 423
            .::.  |:.|      :::.:|:|.|.:  ..|:..:||:...::              |::..|
Zfish   478 HNLMFSVITQAEGMINEIRTAFKGALDD--LKWMDEQTRQAAKDKADAIYDMIGFPDFILDSKEL 540

  Fly   424 --VINGY--AEVNFTQRYEELH-LKPRDYLHNLRTILNHQSLRVKVKTQTSVTYDPVGKRVLLPV 483
              |.:||  .|.||.|.....: ...|.....||...|.....:...| .:..|.|....::.|.
Zfish   541 DDVYDGYEVTEDNFFQNMINFYNFSARVMADQLRKPPNRDQWSMTPPT-VNAYYMPTKNGIVFPA 604

  Fly   484 ALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSC 537
            .:||..| :::.:|||:.:|.:|.::..:|.|:.:|..:           |...|...:..|..|
Zfish   605 GILQAPF-YAQDHPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWQNSSVEAFKNRTEC 668

  Fly   538 FKEQYGRLRLNGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSES-LPQLNLGSRR 601
            ..:||.:..:||.::.......||||||..::.||||||..:.:     .|.|. ||.:||.:.:
Zfish   669 MVDQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQK-----NGEEKRLPAVNLTNDQ 728

  Fly   602 LFFLSFAQLWCNDANEQFRDKQSLFLG------TPNALRVLGALSNFRAFGRDFNCGTASRMTSP 660
            |||:.|||:||:     .|..:|...|      :|...||:|.|||...|...|.|...|.|.|.
Zfish   729 LFFVGFAQVWCS-----VRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSG 788

  Fly   661 QKCQLF 666
            .:|:::
Zfish   789 HRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	168/710 (24%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	170/713 (24%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950