Protein Alignment Nepl19 and MMEL1

DIOPT Version :9

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 834
• Identity: 182/834 - (21%)
• Similarity: 321/834 - (38%)
• Gaps: 260/834 - (31%)

  Fly    10 LLQLLLL---HLVGSG------RGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMR------- 58
            ||.||||   .||..|      ||..|.       |:.:|  |.....:..:|:|..|
Human    29 LLLLLLLVTAALVALGVLYADRRGKQLP-------RLASR--LCFLQEERTFVKRKPRGIPEAQE 84

  Fly    59 ----------LSKSAEMRSYMQQDADACENFYDYSCGNW------PQINPANDAYPRETNFVQLL 107
                      :..:|.:...|....:.|::||.::||.|      |:.|.....:....:.::::
Human    85 VSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVI 149

  Fly   108 LKAYSHKQQRLMEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMP---V 169
            |||       ::|.  :...|..||.:.:..|.||:             .|.::...|..|   :
Human   150 LKA-------VLEN--STAKDRPAVEKARTLYRSCM-------------NQSVIEKRGSQPLLDI 192

  Fly   170 LSLPGQEWPAEEFDWLDTV----------ARIKRQYGFDILL-LF----QQSADR--IYVGQPKQ 217
            |.:.| .||.....|.:||          |.:..|:...:|: ||    .|::.|  ||:.||..
Human   193 LEVVG-GWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTL 256

  Fly   218 ILPE--------ANRKA---------------------------VAEDIANHLERHLGVDPKVAV 247
            .:|.        :|||.                           |.||:...||    ::.::|.
Human   257 GMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLE----LETQLAK 317

  Fly   248 TTAREITEFEQKIAAIMVDRRVGV--MSKLYTPSDADYVDVSKLTQFVETVLDR---ELLANESL 307
            .|..:    |::...|.:..|:|:  :...:.....::      |.|::|||..   :||.:|.:
Human   318 ATVPQ----EERHDVIALYHRMGLEELQSQFGLKGFNW------TLFIQTVLSSVKIKLLPDEEV 372

  Fly   308 YQHVPDYLMKIDELVTETPPHVLANYV--------FNELLKHF-----YYERA------------ 347
            ..:...||..::.::.......:.||:        ...|.:.|     .|.:|
Human   373 VVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWR 437

  Fly   348 ---------------------------ESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYV 385
                                       :|:|.:.:.:||.:|.|.||.:   .:.||.:.|..
Human   438 ECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDEL---GWMDEESKKKA-- 497

  Fly   386 VWQQLQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAEVNFTQRYEELHLKPRDYLHN 450
              |:...|.|.  |....::::.|...:|.|:          |:.:||:   |:|:.:  :.|.|
Human   498 --QEKAMSIRE--QIGHPDYILEEMNRRLDEE----------YSNLNFS---EDLYFE--NSLQN 543

  Fly   451 LRTILNH--QSLRVKVKTQ--------TSVTYDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSL 505
            |:.....  :.||.||...        .:..|.|...:::.|..:|||.| :|:..|:|:.:|.:
Human   544 LKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPF-FSKEQPQALNFGGI 607

  Fly   506 GTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRL--------RLNGHY 551
            |.::..::.|..:|..:           |...|...:.::..|...|||..        .:||.
Human   608 GMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGF- 671

  Fly   552 LPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLG--SESLPQLNLGSRRLFFLSFAQLWCND 614
                :...||||||..::.||.||.:.:||      |  .:.||.|:|...:|||:::||:||..
Human   672 ----NTLGENIADNGGVRQAYKAYLKWMAE------GGKDQQLPGLDLTHEQLFFINYAQVWCGS 726

  Fly   615 ANEQFRDKQSL--FLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            ...:|. .||:  .:.:|...||||:|.|..||...|:|...:.|...::|:::
Human   727 YRPEFA-IQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	161/740 (22%)
		M13	73..664	CDD:189000	161/741 (22%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	163/750 (22%)
		M13	111..777	CDD:189000	161/739 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850