DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl19 and ece1

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	709	Identity:	166/709 - (23%)
Similarity:	288/709 - (40%)	Gaps:	144/709 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQL----------LLKAYSH 113
            :|.::.:...:.:..|.|::||:::||.|.:.||..:...|...|..|          ||:..|.
Zfish    87 VSVASAVLGSLDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSM 151

  Fly   114 KQQRLMEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWP 178
            |.....||.|            :.:|.:|:...:: |:|..:.||:::...|..   .|.| .|.
Zfish   152 KSLSRAEQKA------------QWYYQACMNESKI-EELGAKPLQDLINQTGGW---GLKG-PWE 199

  Fly   179 AEEF-DWLDTVARIKRQYGFDILLLFQQS----ADRIYVGQPKQILPEANRKAVAEDIAN--HLE 236
            .:.| :.|..|:...|...|..:.:...|    ::.|.|.|....||  :|:......||  :|.
Zfish   200 KDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLP--SREYYLNKTANEKYLN 262

  Fly   237 RH----------LGVDPKVAVTTAREITEFEQKIAAI---MVDRR--VGVMSKLYTPSDADYVDV 286
            .:          ||.....:.....||.|||..:|.|   .|:||  ..:..|:.....|.....
Zfish   263 AYLNFLVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRDEEKIYYKIQAKELATLAPA 327

  Fly   287 SKLTQFVETVL-DRELLANESLYQHVPDYLMKIDELVTETPPHVLANYVFNELLKHFYYERAESV 350
            .....|:.:|. ..||..:|.:..:..:||.|:.||::.|...||.||:..::::     :..|:
Zfish   328 IDWMPFLSSVFAPVELNNSEPVVVYAKEYLQKVSELISNTNKSVLNNYMIMKVVR-----KMVSI 387

  Fly   351 VEQ--------------------------CVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQ 389
            ::|                          |||......|..|..:..:....|.:...:..:..:
Zfish   388 LDQKFQDAEQRFLEVMYGTKKSCMPRWKLCVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSE 452

  Fly   390 LQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAEVNFTQRYEELHLKPRD-------Y 447
            ::.:|...|:  :.:|:.|||::...|:.:....:: ||.:  |....:||.....|       |
Zfish   453 IKWAFEDSLK--TVSWMDPETKKAAKEKADAIYNMV-GYPK--FIMNPKELDKVFNDFDVVSDLY 512

  Fly   448 LHNLRTILNHQSLRVKV----------KTQTSVT-------YDPVGKRVLLPVALLQPNFLWSRY 495
            ..|   ::|:.:...:|          :.|.|:|       |:|....::||..:.|..| ::..
Zfish   513 FQN---VMNYYNFSARVTADQLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPF-YNHA 573

  Fly   496 YPKAVRYGSLGTLLAQQLAHSLED-----------ASKWDAKSFAEYSKRKSCFKEQYGRLRLNG 549
            :|||:.:|.:|.::..:|.|:.:|           |..|...|...:..:..|..|||....:|.
Zfish   574 WPKAMNFGGIGVVMGHELTHAFDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINN 638

  Fly   550 HYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSE-SLPQLNLGSRRLFFLSFAQLWCN 613
            ..|.......||||||..:..||.||...:.:     .|.| |||.|.:.:.:|||:.|||:||:
Zfish   639 EPLNGKHTLGENIADNGGLNAAYKAYVNWIKK-----NGEEASLPALGMNNHQLFFVGFAQVWCS 698

  Fly   614 DANEQFRDKQSLFLG------TPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
                 .|..:|...|      :|:..||:|.:||...|...|.|...|.|...:||:|:
Zfish   699 -----VRTPESSHEGVITDPHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKCELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	161/690 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	163/691 (24%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	164/700 (23%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	163/691 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950