DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl19 and mmel1

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	726	Identity:	159/726 - (21%)
Similarity:	286/726 - (39%)	Gaps:	159/726 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LSKSAEMRSYMQQDADACENFYDYSCGNW------PQINPANDAYPRETNFVQLLLKAYSHKQQR 117
            ::.:|.:...|....|.|:|||.|:||.|      |:.:..:..:....:.::::||.....:.:
Zfish    81 VTAAARLLQNMDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELEIVLKGVLEMENK 145

  Fly   118 LMEQPANVETDEVAVLRLKEFYASC---LLFRQVPEDLYRRQLQEIVADFGRMPVLS-----LPG 174
                     .|..|..:.|..|:||   :|..|...    :.|..::...|..||.|     ...
Zfish   146 ---------DDREAFKKAKTLYSSCMNEILIEQRDS----QPLLRLIDSIGDWPVASEVWNGTSE 197

  Fly   175 QEWPAEEFDWLDTVARIKRQYGFD-ILLLFQQSADR------IYVGQPKQILP-------EANRK 225
            |.|..|     ||:|.:..:|... :|.:|....||      |:|.||...:|       :.|.|
Zfish   198 QTWSLE-----DTLAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSDGNYK 257

  Fly   226 AVAEDIANHL---------ERHLGVDPKVAVTTAREITEFEQKI--AAIMVDRR--VGVMSKLYT 277
            .|.|.....:         :|:|..|.:..:....::.|.|..|  |....:.|  :.|:....|
Zfish   258 KVREAYLEFMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYNKMT 322

  Fly   278 PSDADY---VDVSKLTQFVETVLDR---ELLANESLYQHVPDYLMKIDELVTETPPHVLANYV-- 334
            ..:|..   ::....|::::.::..   .:.::|.:..:...||.|:.|::::.....|.||:
Zfish   323 LREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHRTLQNYLVW 387

  Fly   335 -------------FNELLKHFYYERAESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYV- 385
                         |.::..|:......:.||:  :|.||.       :.:.|...|..:..:||
Zfish   388 MLIMDRVSSMSRRFKDVRAHYRKALHGTTVEE--ARWRDC-------VRYVQGNMENAVGALYVR 443

  Fly   386 -------------VWQQLQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAE------- 430
                         :.:::|.::...|:..|  |:..:::.:..|:....|..| ||.:
Zfish   444 ETFSGNSKRMVGELIKKIQEAYVETLEELS--WMDEQSKVKAREKAMAISEQI-GYPDHILEEEN 505

  Fly   431 VNFTQRYEELHLKPRDYLHNLRTIL------NHQSLRVKVKTQ--------TSVTYDPVGKRVLL 481
            ....|.|..|:....:|..|:...|      .|:.||..|...        .:..|.....:::.
Zfish   506 KKLDQEYAHLNFSEENYFENILENLAASAQKGHKKLREPVDPDMWIIGAAVVNAFYSHNRNQIVF 570

  Fly   482 PVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRK 535
            |..:|||.| :|....:|:.:|.:|.::..::.|..:|..:           |...|...:..:.
Zfish   571 PAGILQPPF-FSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQS 634

  Fly   536 SCFKEQYGRLR---LNGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSE-SLPQLN 596
            .|..|||||..   ..|..:.......||||||..::.||.||.:.:..     .|.| .||.|:
Zfish   635 KCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVER-----EGEEPRLPGLD 694

  Fly   597 LGSRRLFFLSFAQLWCNDANEQF------RDKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTAS 655
            :..::||||:|||:||.....::      .|..|     |...||||:|.||.||...|:|...:
Zfish   695 MNHKQLFFLNFAQVWCGACRPEYAIQTIKTDPHS-----PLEYRVLGSLQNFEAFSEAFHCARGA 754

  Fly   656 RMTSPQKCQLF 666
            .|...:||:::
Zfish   755 PMNPEEKCRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	155/707 (22%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	156/708 (22%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	158/717 (22%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	156/708 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950