DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and PHEX

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	763	Identity:	173/763 - (22%)
Similarity:	305/763 - (39%)	Gaps:	160/763 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLHLVGSGRGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMRLSKSAEMRSYMQQDADACENF 79
            :|.||..|.           |.:||:::         |..:...:..:|.:.|.:....|.|:||
Human    36 ILFLVSQGL-----------LSLQAKQE---------YCLKPECIEAAAAILSKVNLSVDPCDNF 80

  Fly    80 YDYSCGNW------PQINPANDAYPRETNFVQLLLKAYSHKQQRLMEQPANVETDEVAVLRLKEF 138
            :.::|..|      |:..|:...||...:.|.|.||       .|:|:..:...|..|:.:.|..
Human    81 FRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLK-------ELLEKSISRRRDTEAIQKAKIL 138

  Fly   139 YASCLLFRQVPEDLYRRQLQEIV--ADFGRMPVLSL---PGQEWPAEEFDWLDTVARIKRQYGFD 198
            |:||:..:.: |....:.|..|:  :.| |.|||..   |...|...:|..|.|:|..:.||...
Human   139 YSSCMNEKAI-EKADAKPLLHILRHSPF-RWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNS 201

  Fly   199 ILLLFQQSADRIYVGQPKQILPEANRK--------AVAED-IANHLERH---------------- 238
            :.:       |:||....:...|...|        ||.|| :.|..|..
Human   202 VFI-------RLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL 259

  Fly   239 LGVDPKVAVTTAREITEFEQKIAAIMVDRRVGVMSKLYTPSDADYVDVSKLTQ---------FVE 294
            ||.:...|....:.:...|.|||.||:.........:|     :.:::|:|:.         :::
Human   260 LGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMY-----NKMNISELSAMIPQFDWLGYIK 319

  Fly   295 TVLD-------RELLANESLYQHVPDYLMKIDELVTETPPHVLANYV--------FNELLKHFYY 344
            .|:|       :::..:|::...||.|...:..::.......:|||:        ...|.:.|.|
Human   320 KVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQY 384

  Fly   345 ERAE--SVV----------EQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGV 397
            ...|  .|:          ::||:.:......::..|..:.|..|...:.:..:.:.::.:|..:
Human   385 RWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM 449

  Fly   398 LQNSSANWLVPETREQLLEQLNTTSLVINGYAE--VNFTQRYEEL---HLKPRDYLHNL---RTI 454
            |:..: .|:...|:.:..|:.... |...||.|  :|.|...|:|   .....||..|:   |..
Human   450 LEKEN-EWMDAGTKRKAKEKARAV-LAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKY 512

  Fly   455 LNHQS---LRVKV-KTQ-----TSVT--YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTL 508
            |....   ||..| ||:     |:|.  |.....::..|...||..|.|...||:::.||::|.:
Human   513 LAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVI 577

  Fly   509 LAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPESDLQ---- 558
            :..:..|..::..:           |..:|..::.::..|...||     :.:|..::.|.
Human   578 VGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQY-----SNYYWKKAGLNVKGK 637

  Fly   559 ---AENIADNLAIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCNDAN-EQF 619
               .||||||..::.|:.|||:.:.:.... |....||.:...:.:|||||:|.:.||... |..
Human   638 RTLGENIADNGGLREAFRAYRKWINDRRQG-LEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAA 701

  Fly   620 RDKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMT-SPQKCQLF 666
            |::..:...:|...||.||:|||..|.:.|||...|.|. ....|:|:
Human   702 REQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	161/699 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	161/701 (23%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	161/701 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920