DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Nepl14

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	738	Identity:	182/738 - (24%)
Similarity:	307/738 - (41%)	Gaps:	136/738 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLLHLVGSGRGHLLTGQ--PAIDLRIQAREQLISQSNDSAYVQRLMRLSKSAEMRSYMQQDADA 75
            |.||.|....:..|::|:  |....||...||.:             |.||:.:|.|::.:..|.
  Fly    11 LWLLWLPHLQQNALVSGEDLPPPFQRIYQSEQTV-------------RRSKAQDMGSHVNKSIDP 62

  Fly    76 CENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQQRLMEQPANVETDEVAVLRLKEFYA 140
            |.:||.|:||||           :.|...|..|:..:.::..|:.:.|....|.|.|.:.||.:.
  Fly    63 CVDFYAYACGNW-----------KSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQAKELFK 116

  Fly   141 SCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPA--EEFDWLDTVARIKRQYGFDILLLF 203
            ||:..:.......:..|.|.:...|..|  ::||.:|..  .:::||..:..::.:||.|||:..
  Fly   117 SCVSAQAHQSQQQQHFLSEFINQNGGFP--AVPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIGL 179

  Fly   204 Q-------QSADRIYVGQPKQILP----EANRKAVAEDIANHLERH----------LGVDPKVAV 247
            :       .:.:.:|:.:|..::|    ..||..:.:.|...||..          ||.|....:
  Fly   180 RVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDESARL 244

  Fly   248 TTAREITEFEQKIAAIMVDRRVGVMSKLYTPSDAD---YV------DVSKLTQFVETVLDRELLA 303
              |.:|..||.::..       |:....:...||:   |:      .:.:.:..:|..||..:.|
  Fly   245 --AADILSFEHELCG-------GMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRA 300

  Fly   304 N------ESLYQHVPDYLMKIDELVTETPPHVLANYVFNELLKHFYY---ERAESVVEQCVSRVR 359
            :      :.:|...|:|..::...|:.....::|||:....:....:   :|.:....:|:.|.:
  Fly   301 SFGQDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDRPQLRKRECLERTK 365

  Fly   360 DLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLV 424
            :|....|..:...|:..|....|:..::..|:.:.|   |:..|.|||..|:....|:|....|.
  Fly   366 ELLPTALGELYARQFGTEDGRIDLDNLYDTLKTALR---QSLGAEWLVEGTQRVGQEKLRNLKLQ 427

  Fly   425 INGYAEVNFTQRYEELHLKPRDYLHNLRTILN-HQSLR--------VKVKTQTSVTYD------P 474
            :..|......    :|.|:..:|..|||.:|. .||.|        :...|.....|:      |
  Fly   428 MPTYERPVIL----KLQLERGNYWQNLRQLLGVVQSQRNNRLFEEFLPAPTDPVEAYEARVRLRP 488

  Fly   475 VGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLED---------ASKWDAKSFAE 530
            |.:|:.:.:|||||. .:...|..|:||.:||..|||||..:.:|         ...||.::..:
  Fly   489 VQRRLDMGLALLQPP-AYDPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGLLERDNWDGQTAWQ 552

  Fly   531 YSKRKSCFKEQYGRLRLNGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDP----SFLGSES 591
            |..|.:||..|     ::.:..|......:.|.|:.||.||:.||...|...:|    :.|..|:
  Fly   553 YHIRSNCFARQ-----VDNYLRPNVSATTQLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKET 612

  Fly   592 LPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFLGTPNA-------------LRVLGALSNFR 643
            ||.||..:..||||::||..|:....:.||:|    |||..             |.|.|.|.|..
  Fly   613 LPDLNYSNTALFFLAYAQEHCSLEEARPRDEQ----GTPEGYLYSARQNHTWTRLLVNGPLRNSV 673

  Fly   644 AFGRDFNCGTASRMTSPQKCQLF 666
            .|..:|.|...|.|....||.::
  Fly   674 EFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	164/671 (24%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	165/672 (25%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	164/671 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850