DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Nepl13

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	180/767 - (23%)
Similarity:	309/767 - (40%)	Gaps:	147/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLQLLLL------HLVGSGRGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMRLSKSAEMRSY 68
            ||:||||      .:..:.:.|:            .|.|:.....||. .::|:|...:.:::.|
  Fly    12 LLELLLLFEIQLCDVTEARQNHM------------NRMQMSGNFPDSR-EEQLVRQKIATDVQKY 63

  Fly    69 MQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKA-YSHKQQRLMEQPANVE------ 126
            |...||.|.:|::|:||.|.:.: .....|.|.:..|.|::. .|.:.|:|:.||...:
  Fly    64 MNLSADPCTDFFEYACGQWGRYH-KRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGY 127

  Fly   127 --TDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVA 189
              .....|.:::.||.||:.......: .||.|.:|:.|.|.:  .::|...|.... .|:.|:.
  Fly   128 SGASMTNVRKVRAFYESCVAVEANASE-RRRFLMKILKDNGGL--RNVPNSNWQHNR-QWVQTLG 188

  Fly   190 RIKRQYGFDILL-------LFQQSADRIYVGQPK-QILPEANRKAVA---------------EDI 231
            .::|.||.||||       |.....:.||.|:|| .|:|..:..|:|               :.:
  Fly   189 ELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQQV 253

  Fly   232 ANHLERHLGVDPKVAVTTAREITEFEQKIAAIMVDRRV---------GVMSKLY----------- 276
            ..:|....|:|...|...|.:|..||.::...|.::.:         .:.:::|
  Fly   254 TENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERL 318

  Fly   277 ------------TPSDADYVDVSKLTQFVETVLDRELLANESLYQHVPDYLMKIDELVTETPPHV 329
                        |....:::|...|   ||.:|:.:.  ...:|...|:|:..:...|.......
  Fly   319 RRQKGGMTLTELTSEMGNHLDFKML---VEVILESQY--PSQVYLRSPEYVKHVVRTVKANNRIT 378

  Fly   330 LANYV----FNELLKHFYYERAESV-VEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQ 389
            :..|:    .|||.:.  .|.|.|. ..|||...:.||.::|..|.....:.:....|:..|:..
  Fly   379 VGGYILYVALNELNQP--PEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFND 441

  Fly   390 LQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAEVNFTQRYEELHLKPRDYLHNLRTI 454
            :   .:.:.:.....|:....|.....:|:...:.:..|..::.|....:   |..||...|...
  Fly   442 V---IKALEEQFHVEWMDENDRRAARTRLSQYRVSLPDYQSLDLTDLQFQ---KSEDYWRRLEIA 500

  Fly   455 LNHQS------LR-------------VKVKTQTSVTYDPVGKRVLLPVALLQPNFLWSRYYPKAV 500
            |.::|      ||             .:|:...|    |..:.||:...|||..: ::.||||::
  Fly   501 LKYRSHQQFEALRGNDFGQDADGLDAFEVRAALS----PRQQMVLVGWGLLQAPY-YNYYYPKSL 560

  Fly   501 RYGSLGTLLAQQLAHSLED---------ASKWDAKSFAEYSKRKSCFKEQYGRLRLN--GHYLPE 554
            :|..||..||..|..:.:|         .::|:..:.:.|.....|.:.||.....|  |.:...
  Fly   561 KYALLGHRLASALVQAFDDEGWNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNA 625

  Fly   555 SDLQAENIADNLAIQVAYHAYRRLLAELDPS---FLGSESLPQLNLGSRRLFFLSFAQ--LWCND 614
            :.|: |.|||...:.:|::||...|.:.|..   .|..|:|.:||..:.:|||:.|||  .|..|
  Fly   626 TRLR-EIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKD 689

  Fly   615 ANEQFRDKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            ..:...|...|...||....|.|.|||...|||:|.|...:.|.|..||.::
  Fly   690 NQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	163/693 (24%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	164/694 (24%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	163/692 (24%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	163/693 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454936
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850