DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Nepl12

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	172/758 - (22%)
Similarity:	313/758 - (41%)	Gaps:	164/758 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLQLLLLHLVGSGRGHLLTGQPAIDL--RIQAREQLISQSNDSAYVQRLMRLSKSAEMRSYMQQD 72
            |:.|:||.::.:.   :||...|..|  |.:..:...|.:|.||...:|...::.  |:|||.|.
  Fly     8 LISLMLLWVIVAA---VLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEF--MKSYMNQS 67

  Fly    73 ADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQQRL----MEQPANVETDEVAVL 133
            .:.|||||:|:|||:..:.|...:....:|...:........:|.|    :.:..|| :.|:||
  Fly    68 VEPCENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNV-SSELAV- 130

  Fly   134 RLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVARIKRQYGFD 198
             .:.||.:||.....|.:........::...|..|  ::.|..|.|..|:|::..|.: ..||.:
  Fly   131 -AQRFYNACLGANLHPFNAADPAYLSLIRSIGGFP--AVDGDAWKASNFNWINMSAHL-ANYGAN 191

  Fly   199 ILLLFQQSADRIYVGQPKQILPEANRKAVAEDIANHLERHLGVDPKVAVTTAREITEFEQKIAAI 263
            .|:  :::....|..:|...|||..        .:|:..|   :..::..|.|.....|:::...
  Fly   192 GLI--RETLQLRYPFEPYTKLPELG--------FDHIIVH---EENISRNTTRAFRLNEERMHGY 243

  Fly   264 MVDRRVGVMSKLYTPSD-------------ADYVDVSKLTQFVETVLDRELLANESLYQHV---- 311
            :  |..|:      |.|             .|.:::....:..:....:.:......|.::
  Fly   244 L--RAFGL------PEDRIREAIAGVFAFWRDALEIPPQCEVFDPYRIKRVFPQSEYYYNISWSG 300

  Fly   312 ---------PDYLMKIDELVTETPPH--VLANYVFNELLKHF-------YYERAESVVEQCVSRV 358
                     ..|.:::|::...   |  .:|||:..:||..|       .|:|....|....| :
  Fly   301 LHSTNKLFCDFYYVELDKVCAR---HRKAVANYLAMKLLYRFDPKLKAPRYQRNYCSVTLYQS-M 361

  Fly   359 RDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETR------------ 411
            |.||.:|   .:...:.:...|:...:| ::|::|.|..|::  |:||..|:|
  Fly   362 RFLFNKL---YMANNFSEAKRLEMSEMV-RELRKSLRKALED--ADWLDAESRARALLKESRIQP 420

  Fly   412 -----------EQLLEQLNTTSLVINGYAEVN------------FTQR-YEEL--HLKPRDYLHN 450
                       ::::.::|:..::.:.|||.|            |:.| ::||  ..||:..|..
  Fly   421 RIGSFQDDALSDRIIREINSLKVIEDRYAETNINLQHLVVQINRFSSRHFQELTNDTKPQKILTG 485

  Fly   451 LRTILNHQSLRVKVKTQTSVTYDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAH 515
            |:....:.:....:.....|...|:                :.|:.|.::::|:||.::..:|.|
  Fly   486 LQVGAGYYTPDNSINVMAGVVEPPI----------------YQRHLPISLKFGTLGFIVGHELIH 534

  Fly   516 SLEDASKW-DAKSFAE----------YSKRKSCFKEQYGRL-------RLNGHYLPESDLQAENI 562
            ..:..|.: |.....|          ...|..|:.:.||:.       |:||    ::.|. |||
  Fly   535 GFDTTSSYFDGNGHMESLLSEISQQALEDRAECYMDYYGKYQVPEISRRVNG----KTTLD-ENI 594

  Fly   563 ADNLAIQ---VAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQS 624
            |||..::   .||.::|:.|.|.......|:::|.|:|...:||||.||||:|:...|:...|..
  Fly   595 ADNSGLRQALTAYRSHRQQLLEHPGQERISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL 659

  Fly   625 LFLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQK-CQLF 666
            ..:.|.:..||||.|||...|...:||...|.|....| |:|:
  Fly   660 SDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGMRPGAKTCRLW 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	153/687 (22%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	151/689 (22%)
Nepl12	NP_649924.1	M13	68..700	CDD:189000	151/689 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850