DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl19 and Ece2

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	186/761 - (24%)
Similarity:	313/761 - (41%)	Gaps:	146/761 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FGIAHALLQLLLLHLVGSGRGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMRLSKSAEMRSY 68
            || :|..|:|:|..|: .....||.| ..:.|.:|.....:   :.:...:..:|:  :.::...
  Rat   200 FG-SHTQLELVLAGLI-LVLAALLLG-CLVALWVQYHRDPV---HSTCITEACIRV--AGKILES 256

  Fly    69 MQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQ---QRLMEQPANVETDEV 130
            :.:....|::||.:|||.|.:.||......|...|..|    :...|   :.|:|. :...:...
  Rat   257 LDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSL----WDQNQAILKHLLEN-STFNSSSE 316

  Fly   131 AVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEF-DWLDTVARIKRQ 194
            |..:.:.||.|||...:: |.|..:.||:::...|...:..    .|..:.| :.|..||...|.
  Rat   317 AERKTRSFYLSCLHLERI-EKLGAKPLQDLIDKIGGWNITG----PWDEDNFMEVLKAVAGTYRA 376

  Fly   195 YGFDILLLFQQS----ADRIYVGQPKQILPE--------ANRKAVAE--DIANHLERHLGVDPKV 245
            ..|..:.:...|    ::.|.|.|....||.        ||.|.:|.  |....|...||..|..
  Rat   377 APFFTVYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAYLDYMVELGMLLGGQPTS 441

  Fly   246 AVTTAREITEFEQKIAAIMV--DRRVG--------VMSKLYT--PSDADYVDVSKLTQFVETVLD 298
            .....:::.|.|.::|.|.|  |:|..        .:|:|.|  ||    :|..:...|:.:.|
  Rat   442 TRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTLAPS----MDWLEFLSFLLSPL- 501

  Fly   299 RELLANESLYQHVPDYLMKIDELVTETPPHVLANYVF-------------------NELLKHFYY 344
             ||..:|.:..:..:||.::.||:..|.|.:|.||:.                   .:||:..|.
  Rat   502 -ELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYG 565

  Fly   345 ERAESVV--EQCVSRVRDLFGELLDHMLFEQYED-------EGTLKDIYVVWQQLQRSFRGVLQN 400
            .:.....  :.|:|...|..|..|..:..:...|       ||.:.:|       :.:|...|:|
  Rat   566 TKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEI-------RAAFEETLEN 623

  Fly   401 SSANWLVPETREQLLEQLNTTSLVINGYAEVNFTQR-----YEELHLKPRDYLHNLRTILNHQSL 460
              ..|:..:||....|:.:....:| |:.:.....|     |:...:....:..|:   ||..:.
  Rat   624 --LVWMDEKTRLAAKEKADAIYDMI-GFPDFILEPRELDDVYDGYEVSEDSFFQNM---LNLYNF 682

  Fly   461 RVKV----------KTQTSVT-------YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTL 508
            ..||          :.|.|:|       |.|....::.|..:||..| ::..:|||:.:|.:|.:
  Rat   683 SAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF-YAHNHPKALNFGGIGVV 746

  Fly   509 LAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPESDLQAENI 562
            :..:|.|:.:|..:           |..:|...:....:|.:|||.:.::||..|.......|||
  Rat   747 MGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENI 811

  Fly   563 ADNLAIQVAYHAYRRLLAELDPSFLGSES-LPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLF 626
            |||..::.||:||:..|.:     .|.|. ||.:.|.:.:|||:.|||:||:     .|..:|..
  Rat   812 ADNGGLKAAYNAYKAWLRK-----HGEEQPLPAVGLTNHQLFFVGFAQVWCS-----VRTPESSH 866

  Fly   627 LG------TPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            .|      :|...||||.|||.|.|.|.|.|...|.|...|.|:::
  Rat   867 EGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	170/687 (25%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	172/688 (25%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	170/692 (25%)
		M13	261..910	CDD:189000	172/688 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850