DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Nepl9

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	145/735 - (19%)
Similarity:	226/735 - (30%)	Gaps:	251/735 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EQLISQSNDSAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQ 105
            :||:...|||                      .|.|::||.::|||:.|        .:|.|...
  Fly    51 QQLVKIKNDS----------------------MDPCDDFYAHACGNFDQ--------TKEENSDD 85

  Fly   106 LLLKAYSHKQQRLMEQPANVETDEVAVLRL-KEFYASCLLFRQ----VPEDL---YRRQLQEIVA 162
            .|.....:||.|:....|.|...|....|| .:.|..|....:    .|..|   :.|.|.||..
  Fly    86 FLPPYLYNKQDRMNFFTAEVGNFETIPGRLISQLYTECRKREERNVFTPTRLTSHWERMLDEIPF 150

  Fly   163 DFGRMPVLSLPGQEWP-----------AEEFDWLDTVARIKRQYGFDILLLFQQSADRIYVGQPK 216
            ......|||    .||           ..:.:|:...|:: ..:|...||....:.|.||| .|.
  Fly   151 LARHKEVLS----SWPFLKHQWERRRLYGQLNWIVLSAQL-AAHGLPTLLHIYFALDTIYV-SPM 209

  Fly   217 QILPEANRKAVAEDIANHLERHLGVDPKVAVTTAREITEFEQKIAAIMVDRRVGV-------MSK 274
            :.||                             ...|.:|:..::.::..|...|       |..
  Fly   210 EELP-----------------------------CPSIADFQSSLSDVLEGRHHQVSRIISHEMRV 245

  Fly   275 LYTPSDADYVDVSKLTQFVETVLDR----ELLANESLYQHVPDYLMKID---------------- 319
            |......:...|..|:|...|...|    :||.:|:...:...|...::
  Fly   246 LCREMRGELPLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYFAALNFSEERLVGARKFPLDV 310

  Fly   320 -------ELVTETPPHVLANYVFNELLKHFYYERAESVVEQCVSRVRDLFGELLD------HMLF 371
                   |::..|...::.|||..:..:...|       ..|. ||.:.|..||.      |:|.
  Fly   311 EKITQAWEVLRHTETRIVYNYVMWQAREQLRY-------PDCY-RVSEEFERLLHAEYWQWHVLR 367

  Fly   372 EQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANW---LVPETREQLLEQLNTTSLVINGYAE--V 431
            .....|..|....:...:.|:..|..|  |..:|   |.|.:.|:  ::|....::.| :||  :
  Fly   368 RHLSREVALASYQLHTTRFQKLRRSKL--SRRDWYGHLWPASVEK--KELQVARILQN-HAENYL 427

  Fly   432 NFT---QRYEELHLKPRDYLHNL----RTILNHQSLRVKVKTQTSVTYDPVGKRVLLPVALL--- 486
            |.|   :.||.|.|:...:..||    |..|.|..:...| .:..|.......|..|...||
  Fly   428 NITELNENYEGLKLEKNSFYANLLILRRAQLRHSFVSPYV-DEEDVNQPAYFLRHFLHFVLLSLH 491

  Fly   487 QPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASKWDAKSFAEYSKRKSCFKEQYGRLRLNGHY 551
            :|.:   .||                ..|.||                  .::|....|..:|||
  Fly   492 RPTY---HYY----------------ATHGLE------------------LWRESRLLLDTDGHY 519

  Fly   552 LPESDLQAENIADNLAIQVAYHAYRRLLAELDPSF--LGSESLPQL------------------- 595
            .....|:.:             :::...|:|.|.:  |||..:.::
  Fly   520 TAMDCLERQ-------------SFQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQ 571

  Fly   596 ---------------NLGSRRLFFLSFAQLWCNDANEQFRDKQSLFLGTPNALRVLGALSNFRAF 645
                           .|...|:.|.:.||..||...|.|            |.::.....|...|
  Fly   572 GERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIF------------AAQLNRGYMNLPEF 624

  Fly   646 GRDFNCGTASRMTSPQKCQL 665
            ...|.||....|..|.:|.:
  Fly   625 QEAFKCGAEKAMNPPSRCMI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	137/699 (20%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	139/700 (20%)
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	10/29 (34%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	17/74 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930