DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Nepl3

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_608904.1	Gene:	Nepl3 / 326172	FlyBaseID:	FBgn0031678	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	720	Identity:	166/720 - (23%)
Similarity:	267/720 - (37%)	Gaps:	256/720 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 MQQDADACENFYDYSCGN--WPQINPANDAYPRETNFVQLLL----------KAYSHKQQRL--- 118
            |.:..:.|.|||:.|..|  |......:|.:       |||.          .::..|.|||
  Fly    38 MDEKVEPCHNFYNSSQKNLKWHAFATVSDQF-------QLLFDGIENEVFEKHSFEEKLQRLYKI 95

  Fly   119 ---MEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAE 180
               ||:|        ::||..|..       :..|||             ..|.|:..|.:||.|
  Fly    96 CSTMERP--------SLLRYFELV-------KPGEDL-------------NWPFLTPRGGKWPKE 132

  Fly   181 EFDWLDTVARIKRQYGF-DIL--LLFQQ--SADRIYVGQPKQILPEANRKAVAEDIANHLE--RH 238
            :|.|::.:||::| ||| ||:  :..:|  ::|.   |||..:..:.     .:.:...:|  ::
  Fly   133 KFQWMEALARLRR-YGFNDIMFGMSIRQDPNSDS---GQPIVVFEKK-----YDSLFRFIESLQN 188

  Fly   239 LGVDPKVAVTTA------REITEFEQKIAAIMVD----RRVGV-MSKLYTPSDADYVDVSKLTQF 292
            :|:.||:|...|      :|:.:.:.|......|    :|:.: ..::|..|         ||::
  Fly   189 IGLPPKLAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEIYGVS---------LTKY 244

  Fly   293 VETVLDRELLAN-----ESLYQHVPDYLMKIDELVTETPPHVLANYV---FNELLKHFYYERAES 349
            :|.|..|....:     |:||     ||..:..|:|..|..|:|||:   |:..:...:.:..:|
  Fly   245 LEIVFGRPFSPDFVVHVENLY-----YLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFMKHGDS 304

  Fly   350 VVEQCVSRVRDLFGELLDHMLFEQ----------YEDE-GTLKDIYVVWQQLQ-RSFRGVLQNSS 402
                ||:.:|... |...::|||:          |::: |.:.|  .:.|||. |..|.||:
  Fly   305 ----CVTTMRQSM-EFASNLLFEERILGRKKLRSYQNQAGKIFD--AIRQQLNIRLERNVLK--- 359

  Fly   403 ANWLVPETREQLLEQLNTTSLVING--------------YAEVNFTQRYEEL---HLKPRDYLHN 450
               |.|.....|.::||..||.|..              |.|:.|... |||   |||
  Fly   360 ---LPPAEISLLQKKLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADD-EELATAHLK------- 413

  Fly   451 LRTILNHQSLRVKVKTQTSVTYDPVGKRVLLPVALLQPNFLWSRY----YPKA-----VRYGSLG 506
               :|.|     :.:.:.|:              |.||||...||    ||.:     ..|...|
  Fly   414 ---VLEH-----RTRAELSL--------------LDQPNFKDRRYMLHSYPISNFFFETAYEENG 456

  Fly   507 TLLAQQLAHS-LEDASKWD--------------------AKSFAEYSKRKSCFKEQYGRLRL--- 547
            ..:  .:|:. |.||| :|                    .|||..:    :|...:...|:|
  Fly   457 NTI--YVAYDFLADAS-FDPDSHDIFKVTPLGIRFGLEMLKSFDLF----NCKHHKVNMLQLFDD 514

  Fly   548 NGHYLPESDLQAENIADNL------------AIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSR 600
            |.......:..:....|||            .:..||.|.....::..|:|        ..:..|
  Fly   515 NQITTAGDECVSAWTQDNLLSQRDQYLVVLHLVHEAYFAEGSKFSQRQPNF--------TTMSLR 571

  Fly   601 RLFFLSFAQLWCNDANEQFRDKQSLFL-------GTPNALRVLGALSNFRAFGRDFNC-GTASRM 657
            .|||..|.|       ..|  .|:|:.       |:|     :.:|:....|.|.||| ....::
  Fly   572 ELFFFRFGQ-------SSF--GQTLYFGSDFVEGGSP-----INSLTRLPVFVRTFNCLAPGEQL 622

  Fly   658 TSPQK 662
            |:.||
  Fly   623 TTTQK 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	163/713 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	165/716 (23%)
Nepl3	NP_608904.1	GluZincin	42..581	CDD:301352	151/661 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740