DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl19 and Phex

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	181/789 - (22%)
Similarity:	312/789 - (39%)	Gaps:	180/789 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NFGIAHALLQLL--------LLHLVGSGRGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMRL 59
            |.||..||...:        ||.||..|.           |..||:::         |..:...:
  Rat    16 NRGIRIALALFITGTLVLGTLLFLVSQGL-----------LSFQAKQE---------YCLKPECI 60

  Fly    60 SKSAEMRSYMQQDADACENFYDYSCGNW------PQINPANDAYPRETNFVQLLLKAYSHKQQRL 118
            ..:|.:.|.:....|.||||:.::|..|      |:..|:...||...:.|.|.|||       |
  Rat    61 EAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKA-------L 118

  Fly   119 MEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIV--ADFGRMPVLSL---PGQEWP 178
            :|:..:...|..||.:.|..|:||:..:.: |....:.|..|:  :.| |.|||..   |...|.
  Rat   119 LEKSVSRRRDTEAVQKAKILYSSCMNEKAI-EKADAKPLLHILRHSPF-RWPVLEANIGPEGVWS 181

  Fly   179 AEEFDWLDTVARIKRQYGFDILLLFQQSADRIYVGQPKQILPEANRK--------AVAEDIANHL 235
            ..:|..|.|:|..:.||...:.:       |:||....:...|...|        ||.||..::.
  Rat   182 ERKFSLLQTLATFRGQYSNSVFI-------RLYVSPDDKASNEHILKLDQATLSLAVREDFLDNT 239

  Fly   236 ERH-----------------LGVDPKVAVTTAREITEFEQKIAAIMVDRRVGVMSKLYTPSDADY 283
            ...                 ||.:...|....:.:...|.|||.||:.........:|     :.
  Rat   240 TEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMY-----NK 299

  Fly   284 VDVSKLTQ---------FVETVLD-------RELLANESLYQHVPDYLMKIDELVTETPPHVLAN 332
            :::|:|:.         :::.|:|       :::..:|::...||.|...:..::.......:||
  Rat   300 MNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIAN 364

  Fly   333 YV--------FNELLKHFYYERAE--SVV----------EQCVSRVRD----LFGELLDHMLFEQ 373
            |:        ...|.:.|.|...|  .|:          ::||:.:..    :.|::..::.|:
  Rat   365 YLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQ- 428

  Fly   374 YEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAEVNFTQRYE 438
             ||:..:.:..:  :.::.:|..:|:..: .|:...|:.:..|:.... |...||.|......|.
  Rat   429 -EDKKEMMEELI--EGVRWAFIDMLEKEN-EWMDAGTKRKAQEKARAV-LAKVGYPEFIMNDTYV 488

  Fly   439 ELHLK-----PRDYLHNL---RTILNHQS---LRVKV-KTQ-----TSVT--YDPVGKRVLLPVA 484
            ...||     ..||..|:   |..|....   ||..| ||:     |:|.  |.....::..|..
  Rat   489 NEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAG 553

  Fly   485 LLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCF 538
            .||..|.|...||:::.||::|.::..:..|..::..:           |...|..::.::..|.
  Rat   554 ELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCM 618

  Fly   539 KEQYGRLRLNGHYLPESDLQ-------AENIADNLAIQVAYHAYRRLLAELDPSFLGSES--LPQ 594
            ..||     :.:|..::.|.       .||||||..::.|:.|||:.:.:...   |.|.  ||.
  Rat   619 INQY-----SNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQ---GVEEPLLPG 675

  Fly   595 LNLGSRRLFFLSFAQLWCNDAN-EQFRDKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMT 658
            :...:.:|||||:|.:.||... |..|::..:...:|...||.||:|||..|.:.|||...|.|.
  Rat   676 ITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTMN 740

  Fly   659 -SPQKCQLF 666
             ....|:|:
  Rat   741 RGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	163/705 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	163/707 (23%)
Phex	NP_037136.2	M13	74..740	CDD:341056	162/700 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920