DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Mme

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	771	Identity:	164/771 - (21%)
Similarity:	285/771 - (36%)	Gaps:	224/771 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ISQSNDSAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNF----- 103
            |.:|:|.        :..:|.:...|...|:.|.:|:.|:||.|.:.|...:...|.:||
  Rat    56 ICKSSDC--------IKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRD 112

  Fly   104 -VQLLLKAYSHKQQRLMEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRM 167
             ::::||       .::::|..  .|.|||.:.|..|.||:             .:..:...|..
  Rat   113 ELEVILK-------DVLQEPKT--EDIVAVQKAKTLYRSCI-------------NESAIDSRGGQ 155

  Fly   168 PVLS-LPG-QEWPAEEFDWLDT----------VARIKRQYGFDILLLFQQSADR-------IYVG 213
            |:|: ||. ..||....:|..|          :|::..:||..:|:.|....|.       |:..
  Rat   156 PLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFD 220

  Fly   214 QPKQILPEAN--------RKA----------VAEDIANHLERHLGVDPKVAVTTAREITEFEQKI 260
            ||:..||..:        ::|          ||..|..  |:.|.:|.........::.|.|::|
  Rat   221 QPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ--EQRLPIDENQLSLEMNKVMELEKEI 283

  Fly   261 AAIMV---DRRVGV-------MSKLYTPSDADY----VDVSKLTQFVETVLDRELLANESLYQHV 311
            |....   ||...:       ::||......:.    ...|..|..:.:.::..:...|.:..:.
  Rat   284 ANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYA 348

  Fly   312 PDYLMKIDELVTETPPHVL--------------------------------------------AN 332
            |:||.|:..::|:..|..|                                            ||
  Rat   349 PEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCAN 413

  Fly   333 YV---FNELLKHFYYERA-----ESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQ 389
            ||   ....:...|.|.|     :.|||..::::|::|.:.||.:
  Rat   414 YVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDL-------------------- 458

  Fly   390 LQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVIN---GYA------EVNFTQRYEELHLKPR 445
                          .|:..||:::..|:    :|.|.   ||.      |......|.||:.|..
  Rat   459 --------------TWMDAETKKKAEEK----ALAIKERIGYPDDIISNENKLNNEYLELNYKEE 505

  Fly   446 DYLHNLRTILNH------QSLRVKVKTQTSVT--------YDPVGKRVLLPVALLQPNFLWSRYY 496
            :|..|:...|..      :.||.||.....::        |.....:::.|..:|||.|..:| .
  Rat   506 EYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAR-Q 569

  Fly   497 PKAVRYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRLR---L 547
            ..::.||.:|.::..::.|..:|..:           |..:|...:..:..|...|||...   .
  Rat   570 SNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLA 634

  Fly   548 NGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSES-LPQLNLGSRRLFFLSFAQLW 611
            .|.:|...:...||||||..|..||.||:..:.:     .|.|. ||.|:|..::||||:|||:|
  Rat   635 GGQHLNGINTLGENIADNGGIGQAYRAYQNYVKK-----NGEEKLLPGLDLNHKQLFFLNFAQVW 694

  Fly   612 CNDANEQFR-DKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            |.....::. :.....:.:|...|::|.|.|...|...|:|...|.|...:||:::
  Rat   695 CGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	157/737 (21%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	158/738 (21%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	157/736 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950