Protein Alignment Nepl19 and ECE1

DIOPT Version :10

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 180/746 - (24%)
• Similarity: 306/746 - (41%)
• Gaps: 137/746 - (18%)

  Fly    13 LLLLHLVGSGRGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMRLSKSAEMRSYMQQDADACE 77
            ::|:.|:.:|   |:....|:.::.|.|...:..|...        :|.::.:.|.|....|.|.
Human    78 VVLVVLLAAG---LVACLAALGIQYQTRSPSVCLSEAC--------VSVTSSILSSMDPTVDPCH 131

  Fly    78 NFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQ---QRLME-QPANVETDEVAVLRLKEF 138
            :|:.|:||.|.:.||..|.:.|...|..|    :.|.|   :.|:| ..|:|...|   .:.:.:
Human   132 DFFSYACGGWIKANPVPDGHSRWGTFSNL----WEHNQAIIKHLLENSTASVSEAE---RKAQVY 189

  Fly   139 YASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVARIKRQYGFDILLLF 203
            |.:|:...:: |:|..:.|.|::...|...:..    .|..:.|.  ||:..:...|........
Human   190 YRACMNETRI-EELRAKPLMELIERLGGWNITG----PWAKDNFQ--DTLQVVTAHYRTSPFFSV 247

  Fly   204 QQSADR-------IYVGQPKQILP-------EANRKAVAEDIANH---LERHLGVDPKVAV-TTA 250
            ..|||.       |.|.|....||       :...:.|.....|:   |.:.||...:.|: ...
Human   248 YVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQM 312

  Fly   251 REITEFEQKIAAIMV------DRRVGVMSKLYTPSDADYVDVSKLTQFVETVL-DRELLANESLY 308
            ::|.:||..:|.|.:      |..: :..|:................|:.|:. ..|:..:|.:.
Human   313 QQILDFETALANITIPQEKRRDEEL-IYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIV 376

  Fly   309 QHVPDYLMKIDELVTETPPHVLANYVFNELLK---HFYYERAESVVEQ----------------- 353
            .:..:||.:|..|:..|...:|.||:...|::   .|..:|.:...|:
Human   377 VYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWK 441

  Fly   354 -CVSRVRDLFGELLDHMLFEQ--YEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETREQLL 415
             |||...:..|..|..|..:.  .||..::....::  :::::|...|  |:..|:..|||:...
Human   442 FCVSDTENNLGFALGPMFVKATFAEDSKSIATEIIL--EIKKAFEESL--STLKWMDEETRKSAK 502

  Fly   416 EQLNTTSLVINGYAEVNFTQRYEELH-------LKPRDYLHNLRTILNHQSLRVKV--------K 465
            |:.:....:| ||.  ||....:||.       ..|..|..|.....|. |.||..        :
Human   503 EKADAIYNMI-GYP--NFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF-SWRVTADQLRKAPNR 563

  Fly   466 TQTSVT-------YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK- 522
            .|.|:|       |.|....::.|..:||..| ::|..|||:.:|.:|.::..:|.|:.:|..:
Human   564 DQWSMTPPMVNAYYSPTKNEIVFPAGILQAPF-YTRSSPKALNFGGIGVVVGHELTHAFDDQGRE 627

  Fly   523 ----------WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPESDLQAENIADNLAIQVAYHAYRR 577
                      |...|...:.::..|..|||....:||..:.......||||||..::.||.||:.
Human   628 YDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQN 692

  Fly   578 LLAELDPSFLGSE-SLPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFLG------TPNALRV 635
            .:.:     .|:| |||.|.|.:.:||||.|||:||:     .|..:|...|      :|:..||
Human   693 WVKK-----NGAEHSLPTLGLTNNQLFFLGFAQVWCS-----VRTPESSHEGLITDPHSPSRFRV 747

  Fly   636 LGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            :|:|||.:.|...|.|...|.|..|.||:::
Human   748 IGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	M13	73..664	CDD:341056	168/682 (25%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	168/682 (25%)