DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and nep-2

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	166/713 - (23%)
Similarity:	292/713 - (40%)	Gaps:	156/713 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SYMQQDADACENFYDYSCGNWPQINPANDAYPRETNF------VQLLLKAYSHKQQRLMEQPANV 125
            |.|....|.|::||:::||.|.:.:|..|..|..:||      ::..||....:.    ::|.:.
Worm    67 SSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDEN----DEPYDY 127

  Fly   126 ETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWL--DTV 188
            ||.  ||.:.|.||..||...:: .|.:|....|:|..||..|  ||..|..|....:.|  |.|
Worm   128 ETS--AVGKAKYFYNLCLNESEI-LDNWRTTFDEVVKSFGGWP--SLGHQMKPDASIEMLYADMV 187

  Fly   189 ARIKRQYGFDILLLFQQSADR------IYVGQPKQILPEANRKAVAEDI---ANHLERH------ 238
            |:.|....|...:   |..|:      :.:.||:..|       .|.|.   |.:.||.
Worm   188 AKFKADSLFKATV---QPDDKNSQRHVLLIDQPQLNL-------FARDFYVAAENEERMAYLQLI 242

  Fly   239 ------LGVDPKVAVTTAREITEFEQKIAAI-MVDRRVGVMSKLYTPSDADYVDVSKLTQFVETV 296
                  |..|...|...|:||.:||..:|.| |.|.....:::|||......:..| |..|...:
Worm   243 RDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRS-LPHFNWPL 306

  Fly   297 LDRELLA--------------NESLYQHVPDYLMKIDELVTETPPHVLANYV-----FNELLKHF 342
            ....:..              |..:..:..::|.::|.|:.:....::.||:     |..:|:..
Worm   307 FFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDL 371

  Fly   343 ----------YYERAESVVEQ------CVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQ 391
                      :|:....:..|      ||:|:..|.......:..:.:.|....:.:..:...:.
Worm   372 PDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIM 436

  Fly   392 RSFRGVLQNSSANWLVPETREQLLEQ-------------LNTTSLVINGY------------AEV 431
            .||..:|  .|.:||..||::...::             ||..:.|.|.|            .:.
Worm   437 ESFVDLL--LSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKF 499

  Fly   432 NFTQRYEELHLKPRDYLHNLRTILNHQSLRVKVKTQTSVTYDPVGKRVLLPVALLQPNFLWSRYY 496
            :|.::|:      ||.|..:...::.:.. |......:..|.|....::.|..:|||.| :|:.:
Worm   500 SFYEQYQ------RDVLERITEAVDRERW-VAGAALVNAFYSPNTNEIIFPAGILQPVF-YSKDF 556

  Fly   497 PKAVRYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYG------- 543
            |.::.:|.:|.::..::.|..:|..:           ||..:.:::..:..|.::||.
Worm   557 PSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQI 621

  Fly   544 RLRLNGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFA 608
            .:::||     ...:.||||||..::.||.||::    .:........||.:||...:||||::|
Worm   622 NMQING-----KSTKGENIADNGGLKQAYRAYKK----YEKRHSRPPRLPGVNLTHDQLFFLNYA 677

  Fly   609 QLWCNDANEQFRDKQSL-FLGT----PNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            |:||...|    ||::: .|.|    |..:||.|.|||...|.:.:||...|:|...:||:::
Worm   678 QIWCGTMN----DKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	163/702 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	163/703 (23%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	166/711 (23%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	163/703 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920