Protein Alignment Nepl19 and nep-8

DIOPT Version :9

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 668
• Identity: 134/668 - (20%)
• Similarity: 261/668 - (39%)
• Gaps: 146/668 - (21%)

  Fly    59 LSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQQRLMEQPA 123
            ::.|.|:.:|.....|.|.:|:.:|||.:.:.:.:.....::.:.::..::.:.||.|....:..
 Worm    62 ITLSHELLNYQDPSVDPCVDFFQHSCGRFHEQSVSESRLQKKKHILRKQIREFLHKIQNSTSKSE 126

  Fly   124 NVETDEVAVLRLKEFYASCLLFRQVPEDLY---RRQLQEIVADFGRMPVLSLPGQEWPAEEFDWL 185
            |:         :|..:..|...::...|.|   |..:.::..|..::....|..:.|...:||..
 Worm   127 NL---------MKLVFDKCEASKKTSNDNYKISRDAIHDVFNDIKKIGAWPLLDKNWDGSKFDLN 182

  Fly   186 DTVARIKRQYGFDILLLFQQSADRIYVGQPKQILPE----ANRKAVAEDIANHLERHLGVDPKVA 246
            :.::.:.: .|...|.|||.....:..|:..:|.|.    .:...:...|:..||.: ||.|
 Worm   183 EMLSNLVK-LGATNLGLFQLDFRILTEGKFVRIAPTLGSIVHNSTMISMISEILEAN-GVQP--- 242

  Fly   247 VTTAREIT-EFEQ------KIAAIMVDRRVGV---------MSKLYT----PSDADYVDVSKLTQ 291
              .:.||: |||:      |:|......::.:         .|.|.|    ||     .|||:..
 Worm   243 --DSEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLITEMIHPS-----RVSKIFG 300

  Fly   292 FVETVLDRELL---ANESLYQHVPDYLMKIDELVTETPPHVLANY-VFNELLKHFYYERAESVVE 352
            .:..|.....|   :||:         ..:|.::..|....|||: :||      |.:.:.::::
 Worm   301 KIRVVTSEHPLFFKSNET---------ESLDTIIESTSNKTLANFLIFN------YIQSSYNIMK 350

  Fly   353 -----QCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETRE 412
                 .|...||..|......:....:.|:|....:..:.::|:::...::|::..  |.|..:|
 Worm   351 GARRGNCEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTEN--LAPPVKE 413

  Fly   413 QLLEQLNTTSLVINGYAE-----VNFTQRYEELHLKPRDYLHNLRTILNHQSLRVKVKTQTSVTY 472
            .:|:::....:.| ||.:     ....:.:|...|...|..:.:...||    |::.:.|....
 Worm   414 SMLKKVEAIKVTI-GYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLN----RLRSEQQMEFI- 472

  Fly   473 DPVGKRVLLPV-ALLQPNFLWSR-------------------YYPKAVRYGSLGTLLAQQLAHSL 517
              .|:..:.|: .:|:.|..:.|                   .||..|.....|.|:|.::.||:
 Worm   473 --AGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFSGFLIAHEIGHSV 535

  Fly   518 --------EDASKWDA---KSFAEYSKRKSCFKEQYGRL-------RLNG-HYLPESDLQAENIA 563
                    |:....|.   :...||.|:..|..:||...       ::|| |.:.|.      ||
 Worm   536 DANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEI------IA 594

  Fly   564 DNLAIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFLG 628
            |.:..:|.:.||:::......|.:|   |..:|:.  :|:|...:.|:|.:     ||..||
 Worm   595 DWVGHEVTWRAYKKMDTSKMLSLIG---LKDINMD--QLYFRVQSLLFCRE-----RDTISL--- 646

  Fly   629 TPNALRVLGALSNFRAFG 646
             ...|:.:....|||..|
 Worm   647 -EETLKDVYPTDNFRVNG 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	132/660 (20%)
		M13	73..664	CDD:189000	131/654 (20%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	131/654 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920