Protein Alignment Nepl19 and nep-6

DIOPT Version :10

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_494537.1
• Gene: nep-6 / 184628
• WormBaseID: WBGene00017550
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 692
• Identity: 145/692 - (20%)
• Similarity: 276/692 - (39%)
• Gaps: 150/692 - (21%)

  Fly    64 EMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQQRLMEQPANVETD 128
            ::.::.....|.|::||..:||.:.:...||....::...:|.::|.:..|.:....:..||
 Worm    96 QLLNFQDPSVDPCQDFYKAACGKYSEHEVANRRLQKKDIIIQRMIKNFLLKNETSESKSENV--- 157

  Fly   129 EVAVLRLKEFYASCLLFRQVPEDLYRRQL----QEIVADFGRMPVLSLPGQEWPAEEFDWLDTVA 189
                  :::.|.:|...:.  |:::...:    :|:..|..::       ..|||.:.:|.:|..
 Worm   158 ------MRQVYRTCEGLKN--EEIFNANMKTAFRELFKDIQKI-------GSWPAADKNWDETKL 207

  Fly   190 RIKR------QYGFDILLLFQQSADRIYVGQP-KQILPE--------ANRKAVAEDIANHLERH- 238
            .:..      :.|.....|||.....:    | .::.|:        ||.:.:..||   ||::
 Worm   208 NLNEMLLNIVKLGSSNFGLFQIRPTEV----PFLEVAPDMARSPKVSANFQQIIFDI---LEKNG 265

  Fly   239 LGVDPKVAVTTAREITEFEQKIAAIMVDRRVGVM--SKLYTPSDADYVDVSKLTQFVETVLD--- 298
            |..|..|......:....|:.::....|.....:  |||..     .|...||.:.:|.:::
 Worm   266 LQPDENVIADDVEDYITLEETLSQYAYDYNAEKVQFSKLQA-----QVPSLKLEKIIEEMMNPNR 325

  Fly   299 RELLANE----------SLYQHVPDYLMKIDELVTETPPHVLANYVFNELLKHFYY-ERA----- 347
            ::||..:          ||:.   |..|.:::|:..||...||||:.      ||| :.|
 Worm   326 KKLLVTKVKPRMVAHKHSLFF---DEKMNLEKLLKSTPKRTLANYLI------FYYMDHAMNGLS 381

  Fly   348 --ESVVEQ--CVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVP 408
              ::|:::  |...|.:...:....:....:.::|.||.:..:.::.::||..:||.|:  ||..
 Worm   382 VHDNVIKKRNCEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMAEETKKSFIEMLQEST--WLGA 444

  Fly   409 ETREQLLEQLNTTSLVINGYAEVNFTQR------YEELHLKPRDYLHNLRTILN--HQSLRVK-V 464
            ::::..:.:|.....:| ||.: .|.::      :|.|.|.|:|.|:.:...:.  |....:: |
 Worm   445 DSKKNAILKLEKMGKMI-GYPK-EFEKKGALDKMFETLKLLPKDTLYGILKKIGRFHMEQGIEFV 507

  Fly   465 KTQTSVTYDPVGKRVLLPVALLQPNF----------------LWSRYYPKAVRYGSLGTLLAQQL 513
            ..:|.:  |||     |||.:....:                |:...|||.|.....|.:||.:.
 Worm   508 ALETPM--DPV-----LPVLMTNAFYTDRNHLSFLVGYMDDPLFDATYPKYVNIALTGNILAHET 565

  Fly   514 AHSLEDAS----------KW-DAKSFAEYSKRKSCFKEQYGRL-------RLNGHYLPESDLQAE 560
            :|..:.|.          .| ..:...||.|:..|..:||...       .|||     :....|
 Worm   566 SHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGKNLNG-----TTTLNE 625

  Fly   561 NIADNLAIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCN-DANEQFRDKQS 624
            .:||.:.:.||:..:.:|.:..:...:|.|     |....:|:|.:.|..:|: .......::.:
 Worm   626 MVADMIGVTVAWKVFEKLDSSKEQKVIGFE-----NENIDKLYFRAAALDFCSLPPTTSLVEELT 685

  Fly   625 LFLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            ....|.| .||.|..||...|...|||...|.|....:|.:|
 Worm   686 RVHPTGN-FRVNGIFSNMPQFATAFNCPEGSPMNPKTRCSIF 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	M13	73..664	CDD:341056	143/679 (21%)
nep-6	NP_494537.1	M13	105..724	CDD:341056	143/679 (21%)