Protein Alignment Nepl19 and nep-22

DIOPT Version :10

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 728
• Identity: 146/728 - (20%)
• Similarity: 257/728 - (35%)
• Gaps: 161/728 - (22%)

  Fly    69 MQQDADACENFYDYSCGNWPQINPAND-AYPRETNFVQLLLKAYSHKQQRLMEQPANVETDEVAV 132
            :....|.|::||.::|..:.|...... ...|...:.|..:..||.....|.:......|.....
 Worm    79 LDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAALSKIDVTSTTTSKTE 143

  Fly   133 LRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVARIKRQYGF 197
            ...|..:.:|......|.|.......||.:.||.:|....|.:    ...|:.....:|::::..
 Worm   144 RITKAAFETCKNNLASPADKTAVVYAEITSLFGGVPFFGEPLK----TNVDYWMVAGQIEQKHAV 204

  Fly   198 DILLLFQQSAD-------RIYVGQP-----------KQILPEANRKAVAEDI-------ANHLER 237
            ..|.....|:|       .:|.|.|           .|.:.|.|::  ..|:       ||..::
 Worm   205 GTLTYTIASSDYKDHTKNALYTGPPGLSLARDFYVKPQYIAEVNQR--VSDVNDLLTAFANAAKK 267

  Fly   238 HLGVDPKVAVTTAREITEFEQKIA-AIMVDRRVGVMSKLYTP-----SDADYVDV---SKLTQFV 293
            ::|.|..:|  .|:|:..||.:|| |...|..:....:.|.|     :...|..:   |.|.|..
 Worm   268 NVGADALLA--AAQEVVNFEVQIAMASWPDDLLRNYQQQYNPYNIASATTAYRAINWKSYLGQLF 330

  Fly   294 ETVLDRELLANESLYQHVPDYLMKIDELVTETPPH--VLANYVFNELL----------------- 339
            ..|......||.::....|.|...::.:......:  |:|||:..:||
 Worm   331 HGVASDADQANYNIVVTEPSYFAWLNSVFDGKTSNSTVVANYMIAQLLADESDFINPATAKVSSD 395

  Fly   340 -KHFYYE----RAESVVEQCVSRVRDLFG------ELLD-HMLF-----------EQYEDEGTLK 381
             .:.:|.    |....:.:...|:.||.|      :||. :|.:           |:.:.:..:|
 Worm   396 TNYIHYALRNGRGIKKIGKREYRMADLDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVK 460

  Fly   382 DIYVVWQQLQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVIN-GYAEVNF------------ 433
            |...:   :..:|:|::  .|.||:  :|..:......:.|||.| |:.|..|
 Worm   461 DQTTL---IINNFQGMI--DSLNWM--DTFSKNRAHNKSDSLVKNFGWPEAMFGDFNDFTTVDAY 518

  Fly   434 TQRYE---ELHLKPRDYLHNLRTILN-----HQSLRV-----------KVKTQTSVTYDPVGKRV 479
            .|.|.   :|:.|.::.::.:..:|.     .:..|:           :.....:..|.|....:
 Worm   519 NQDYASIIDLYTKDKNDIYGIFAVLKKGMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSI 583

  Fly   480 LLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDAS------------KW------DAK 526
            ..|.|...|.: ::..||:|..:...|.....:|.|..:|..            .|      |..
 Worm   584 TFPYAAWNPPY-YNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTN 647

  Fly   527 SFAEYSKRKSCFKEQYG-----RLRLNGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSF 586
            |.:.:.....|...|:.     ....|.|....:..|.|||||....|.||.:||:.:|.....
 Worm   648 SSSGFIDMAQCVVTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKG- 711

  Fly   587 LGSESLPQL-NLGSRRLFFLSFAQLWC---NDAN---EQFRDKQSLFLGTPNALRVLGALSNFRA 644
            :..:.||.| |....::|::::...||   :|||   :...:..|     |...|....:.:...
 Worm   712 VEEDRLPGLENYTPNQIFWITYGYSWCMKQSDANLVHQLLTNPHS-----PAQCRTNQVMQDIPE 771

  Fly   645 FGRDFNCGTASRM 657
            ||:||.|...|.|
 Worm   772 FGKDFGCVRGSPM 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	M13	73..664	CDD:341056	146/724 (20%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	146/724 (20%)