DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and nep-17

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	173/832 - (20%)
Similarity:	291/832 - (34%)	Gaps:	284/832 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GQPAI--DLRIQAREQLISQSND--SAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNWPQ 89
            |.|.:  |:.:.....:.|.:.|  :||...:...:||      :....|.|::||.|:|||:
Worm   842 GLPNVKTDINVVPEAPITSTNVDKMNAYQMAVDYYAKS------VNTAIDPCDDFYSYACGNF-- 898

  Fly    90 INPANDAY-PRETNFVQLLLKAYSHKQQRLMEQPANVET--DEVAVLRLKEFYASCL--LFRQVP 149
             |.:...| .|..|.|.:..|         :|.|....|  ...|:.:.|:.|.:||  ......
Worm   899 -NQSVSFYTARAQNLVYMAQK---------LEDPTYQTTINSSPALKKEKQLYNACLTATASSQS 953

  Fly   150 ED---LYRRQLQEIVADFGRMPVLSLPGQEW---------------------------------- 177
            ||   :.:..:|..|.|     :.:|.||::
Worm   954 EDQILISKNYIQTKVDD-----LKTLIGQDFTLVNGGAPKLPSAKQIGDALGYLSFEQGIDTLIS 1013

  Fly   178 PAEEFDWLD-----------TVARIKRQYGFDILLLFQQSADRIYVGQPKQILPEANRKAVAEDI 231
            |..:..|:|           ..|.:.:.|       :|.:|.:|  .:||.:       .:|.|:
Worm  1014 PLVDTYWIDNSKGYQMFIDQNTAYLSKTY-------YQPAAWKI--EKPKYL-------KMALDV 1062

  Fly   232 ANHLERHLGVD-PKVAVTTAREITEFEQKIAA-IMVD---RRV---------------------- 269
            .....|...:. |..|......:.::||.||. ...|   ||.
Worm  1063 VTRYAREQNITLPAGASDLLSNVLDYEQNIAVKYSTDDNTRRQFQRSWNLTKTSDLVTKYNFMDW 1127

  Fly   270 ---------GVMSKLYTPSDADY----VDVSKLTQFVETVLDR--ELLANESLY--------QHV 311
                     .|.:|:   :||:|    ::|.:||.|....|.:  |||.| .|:        |::
Worm  1128 MTYLSHAPNAVKAKI---TDANYQVSVMEVDRLTHFSADYLQQSPELLVN-LLFVRLLLGNAQYI 1188

  Fly   312 PDYLMKIDELVTET-----------PPHV--------------------LANYVFNELLKHFYYE 345
            |.|......:..|:           |.|:                    |..:....:...:.|.
Worm  1189 PSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASVANNLMQFANGRVFVDYMYP 1253

  Fly   346 RAESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPET 410
            .|     |.|:.:|...|              |.:|::.       .||:|::  ...:|:.|:|
Worm  1254 TA-----QDVTNIRKSAG--------------GIIKNVI-------SSFQGMI--DQLDWMAPDT 1290

  Fly   411 REQL------LEQ-------LNTTSLVINGYAEV------NFTQRYEELHLKPRDYLHNLRTILN 456
            :::.      ::|       :...:|:.|.|:.:      ||...|        |.|......:.
Worm  1291 KQKAYAKTVQIQQNIAFPDWIKNDTLLGNYYSTLVIADSDNFYDIY--------DKLIKFNIFVQ 1347

  Fly   457 HQSLRVKVKTQT---------SVTYDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQ 512
            :..|......:|         :..|.|....:..|..:|.|.: ::..:|.::.||.:|.:...:
Worm  1348 YNQLNAAQTDRTDFLGQPGTVNAWYQPELNSITFPAGILVPPY-FNPNWPPSINYGGMGLVAGHE 1411

  Fly   513 LAHSLED----------ASKW-DAKSFAEYSKRKSCFKEQY-GRLRLNG-HYLPE----SDLQAE 560
            |.|..:|          .::| |..|.|.:.....|...:| |...||. :|.|.    ...|.|
Worm  1412 LTHGFDDQGVQWGPTGNLARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGE 1476

  Fly   561 NIADNLAIQVAYHAYR--RLLAELDPSFLGSESLPQLNLGS---RRLFFLSFAQLWCNDANEQFR 620
            |||||..:..|::||:  :.|...||      .||....|.   .:|||:||||:||    |..|
Worm  1477 NIADNGGVHAAFNAYKTHQSLDGPDP------RLPDRLFGQFTHDQLFFMSFAQVWC----EVRR 1531

  Fly   621 DKQSLFL------GTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            ...:|:.      .:|:..||.|.:.||.||...|||...|:....|.|:::
Worm  1532 TDDALYTQIMVDPHSPSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	162/779 (21%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	163/780 (21%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	164/786 (21%)
		M13	884..1581	CDD:189000	163/780 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020