DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and nep-1

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	740	Identity:	170/740 - (22%)
Similarity:	299/740 - (40%)	Gaps:	155/740 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IQAREQLISQSNDSAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRET 101
            ::..::..:..:...|.:....|.||..:      ..|.|::|::|:|..|...:|..|.....:
Worm    54 VEEEKKTYTVGDSEGYQEASRLLQKSLNL------SLDPCDDFFEYACRAWVDSHPIPDDLTSYS 112

  Fly   102 NFVQLLLKAYSHKQQRLMEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYR------RQLQEI 160
            .|.....|..: :.::|.|...::.|.: ::..:|:.|.:|:       |..:      |.|.|.
Worm   113 QFTATREKVLA-EMRKLYEDNTSIPTSK-SIALIKQIYNTCM-------DTEKHNAVGARDLLEK 168

  Fly   161 VADFGRMPVLSLPGQEWPAEEFDWL----DTVARIKRQYGFDI------------LLLFQQ---- 205
            :..:|..|::.  .::|....||..    :|:........||.            ||.|.|
Worm   169 IKTYGYWPMVH--NEKWRESTFDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLG 231

  Fly   206 ---SADRIYVGQPKQILPEANRKAVAEDIANHLERHLGVDPKVAVTTAR------EITEFEQKIA 261
               |....|:.:.|.   |...||..:.....: |:...|..:||..::      ||..||::.|
Worm   232 LGYSTRDYYLDEKKY---EKQMKAYRKYTIGKV-RYYTEDAGMAVNESKIESDVDEIIAFEKEWA 292

  Fly   262 AIMV---DRRVGVMSKLYTPSDAD-------YVDVSKLTQFVETVLDRELL-ANESLYQHVPDYL 315
            .|:|   |||  ..:|||.....|       .:|..|||......|....| .|.|:.....:||
Worm   293 QILVAEEDRR--NYTKLYNVRRFDDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYL 355

  Fly   316 MKIDELVTETPPHVLANYV---------------FNELLKHFYYE-----RAESVVEQCVSRVRD 360
            .|::.|:..|.|.::.||:               :.:|.:.|.::     :.:...:.|||....
Worm   356 QKMNTLLQNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGG 420

  Fly   361 LFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETR-------EQLLEQL 418
            ........|...:|.|.........:...||.:||.::.  :.:|:..||:       :|:|:|:
Worm   421 KLSYASGSMYVRKYFDANAKNTTLDMITDLQEAFRNMMH--ANDWMDAETKKYALEKADQMLKQI 483

  Fly   419 NTTSLVIN------------GYAEVNFTQRYEE-LHLKPRDYLHNLRTILNHQSLRVKVKTQTSV 470
            .....::|            |..|.:|:|..|: :..:...|...|...:|    |.:..:..:|
Worm   484 GYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFYYRRLLEPVN----RFEFISSAAV 544

  Fly   471 T---YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK---------- 522
            .   |.|....:..|..:||..|..:| :|||:.||.:|.::..::.|..:|..:
Worm   545 VNAFYSPTRNAIAFPAGILQQPFFDAR-FPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRD 608

  Fly   523 -WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPESDL-------QAENIADNLAIQVAYHAYRRLL 579
             ||..:.:::::|..|..|||..::|.|     :||       |.||||||..|:.|:.||:..|
Worm   609 WWDNTTSSKFNERTQCIIEQYADVKLRG-----TDLRINGKLTQGENIADNGGIKQAFKAYKSYL 668

  Fly   580 AELDPSFLGSES-LPQL-NLGSRRLFFLSFAQLWCNDANEQFRDKQSLFLGT----PNALRVLGA 638
            .:..    |.|: |||. :|.:.:|||:.:||:||   ..:..:.::|.|.|    |...||...
Worm   669 EKHG----GQEARLPQFESLTNEQLFFVGYAQVWC---GAKTPETKTLLLLTDPHSPETARVNTV 726

  Fly   639 LSNFRAFGRDFNCGTASRMTSPQKC 663
            |:|...|...|.|...|.|...::|
Worm   727 LTNQPEFAEAFKCPAGSPMNPTKRC 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	164/702 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	166/704 (24%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	166/714 (23%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	165/701 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850