Protein Alignment Nepl19 and nep-12

DIOPT Version :9

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 723
• Identity: 161/723 - (22%)
• Similarity: 299/723 - (41%)
• Gaps: 142/723 - (19%)

  Fly    48 NDSAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYS 112
            |.:......:||  :|...:.|.:||:.||:||:::||.:.......: :.::...:..:.|...
 Worm   148 NSTCLTPECIRL--AASYLNNMNRDANPCEDFYEFACGKYATRKVIAE-HEKKVTVLSEMKKEMD 209

  Fly   113 HKQQRLMEQPANVETDEVAVLRLKEFY-ASCL-LFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQ 175
            ...:.::|:.:...|  ...::|.:.| .||: .|.|  :||..:.|..::::.|..|:|:  ..
 Worm   210 RHLKDILEKTSRENT--TRSMKLAQIYFDSCMDEFSQ--DDLGVQPLMSMISNLGGWPLLT--NA 268

  Fly   176 EWPAEEFDWLDTVARIKRQYGFD-ILLLFQQS----ADR--IYVGQPKQILPEAN--RKAVAEDI 231
            .:.:.:|.| :.:|.....||.| |..:|..|    :|:  :....||..|.:..  |:..:.::
 Worm   269 RFDSIDFQW-EVLAGHLALYGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSNV 332

  Fly   232 ANHLERH--------LGVDPK----VAVTTAREITEFEQKIA---AIMVDRRVGVMSKLYTPSD- 280
            .....|.        ||||.:    |......:|.:||::||   .|.:.|....::.:.|..:
 Worm   333 YLQYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFERRIANLTRIELSRNHSSINNMITFGEF 397

  Fly   281 -ADYVDVSKLTQFVETVLDRELLAN-----ESLYQHVPD--YLMKIDELVTETPPHVLANYVFNE 337
             ..|..::     .:...:.|:..|     :||..:|.|  |...:..|:...|...:.|::...
 Worm   398 KRKYDKIN-----WDAFFNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWC 457

  Fly   338 LLKHF------YYERA--------------ESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKD 382
            |:.::      .|.:.              :.:.|.||..||    |.|...|..:|..:...|.
 Worm   458 LVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVR----ENLAMPLSTEYAQKFFTKK 518

  Fly   383 IYVVWQQLQRSFRGVLQNS--SANWLVPETREQLLEQ--------------LNTTSLVINGYAEV 431
            ..:|.:.:.|..:..::.:  :|:|:...|||..|.:              ||.|:::: .||.|
 Worm   519 DKLVAEDMIRDLKKAMEQTLLNADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLL-PYAGV 582

  Fly   432 NFT--QRYEE-LHLKPRDY------LHNLRTILNHQSLRVKVKTQTSVTYDPVGKRVLLPVALLQ 487
            ..|  |.::. :.||...|      ||...::::..|..:.|......|    |..::.|..:||
 Worm   583 RLTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHYFT----GNEIIFPAGILQ 643

  Fly   488 -PNFLWSRYYPKAVRYGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKE 540
             |.|:...  |....||::|..:..::.|..:|...           |..::...:.|:|.||..
 Worm   644 FPMFVPDA--PAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVA 706

  Fly   541 QYGRLRLNGHYLPESDLQ-------AENIADNLAIQVAYHAYRRLLAELDPSFLGSESLPQL-NL 597
            |||     ....|::..:       .||||||..::||:.|| :|.::.:..   :..||.| :.
 Worm   707 QYG-----SKIEPQTGRKVDGKMTIGENIADNGGLRVAFQAY-QLRSDREKE---TRRLPGLTDF 762

  Fly   598 GSRRLFFLSFAQLWCN----DANEQFRDKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMT 658
            ...:||||::|..||.    .|.:...|.....||   ..||...|.|..||.::|:|...|.|.
 Worm   763 SPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLG---MFRVNVPLQNLPAFSKEFDCPIGSPMN 824

  Fly   659 SPQKCQLF 666
            ..:||:::
 Worm   825 PFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	154/693 (22%)
		M13	73..664	CDD:189000	154/694 (22%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	154/694 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880