DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Mme

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	766	Identity:	162/766 - (21%)
Similarity:	286/766 - (37%)	Gaps:	214/766 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ISQSNDSAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNF----- 103
            |.:|:|.        :..:|.:...|....:.|.:|:.|:||.|.:.|...:...|.:||
Mouse    56 ICKSSDC--------IKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRD 112

  Fly   104 -VQLLLKAYSHKQQRLMEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRM 167
             ::::||       .::::|..  .|.|||.:.|..|.||:....: :....:.|.:::.|....
Mouse   113 ELEVILK-------DVLQEPKT--EDIVAVQKAKTLYRSCINESAI-DSRGGQPLLKLLPDIYGW 167

  Fly   168 PVLS-----LPGQEWPAEEFDWLDTVARIKRQYGFDILLLFQQSADR-------IYVGQPKQILP 220
            ||.|     ..|..|.||:     ::|::..:||..:|:.|....|.       |:..||:..||
Mouse   168 PVASDNWDQTYGTSWTAEK-----SIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLP 227

  Fly   221 EAN--------RKA----------VAEDIANHLERHLGVDPKVAVTTAREITEFEQKIAAIMV-- 265
            ..:        ::|          ||..|..  |:.|.:|.........::.|.|::||....
Mouse   228 SRDYYECTGIYKEACTAYVDFMISVARLIRQ--EQSLPIDENQLSLEMNKVMELEKEIANATTKP 290

  Fly   266 -DRRVGVMSKLYTPS-------------DADYVDVSKLTQFVETVLDRELLANESLYQHVPDYLM 316
             ||...::  ||...             :......|..|..:.:.::..:...|.:..:.|:||.
Mouse   291 EDRNDPML--LYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLT 353

  Fly   317 KIDELVTETPPHVL--------------------------------------------ANYV--- 334
            |:..::|:..|..|                                            ||||
Mouse   354 KLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGN 418

  Fly   335 FNELLKHFYYERA-----ESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSF 394
            ....:...|.|.|     :.|||..::::|::|.:.||.:
Mouse   419 MENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDL------------------------- 458

  Fly   395 RGVLQNSSANWLVPETREQLLEQLNTTSLVIN---GYA------EVNFTQRYEELHLKPRDYLHN 450
                     .|:..||:::..|:    :|.|.   ||.      |......|.||:.:..:|..|
Mouse   459 ---------TWMDAETKKKAEEK----ALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFEN 510

  Fly   451 LRTILNH------QSLRVKVKTQTSVT--------YDPVGKRVLLPVALLQPNFLWSRYYPKAVR 501
            :...|..      :.||.||.....::        |.....:::.|..:|||.| :|.....::.
Mouse   511 IIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPF-FSAQQSNSLN 574

  Fly   502 YGSLGTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRLR---LNGHYL 552
            ||.:|.::..::.|..:|..:           |..:|...:..:..|...|||...   ..|.:|
Mouse   575 YGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHL 639

  Fly   553 PESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSES-LPQLNLGSRRLFFLSFAQLWCNDAN 616
            ...:...||||||..|..||.||:..:.:     .|.|. ||.|:|..::||||:|||:||....
Mouse   640 NGINTLGENIADNGGIGQAYRAYQNYVKK-----NGEEKLLPGLDLNHKQLFFLNFAQVWCGTYR 699

  Fly   617 EQFR-DKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            .::. :.....:.:|...|::|.|.|...|...|:|...|.|...:||:::
Mouse   700 PEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	155/732 (21%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	156/733 (21%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	156/733 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850