DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	776	Identity:	173/776 - (22%)
Similarity:	303/776 - (39%)	Gaps:	185/776 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GIAHALLQLLLLHLVG----SGRGHLLTGQPAIDLRIQAREQLISQSNDSAYVQRLMRLSKSAEM 65
            |:...|..:|.|..:|    .|.|....|.|  :.:..||......:|..|.:
Mouse    71 GLCAILAAMLALKYLGPGAAGGGGACPEGCP--ERKAFARAARFLSANLDASI------------ 121

  Fly    66 RSYMQQDADACENFYDYSCGNWPQINPANDAYPRET---NFVQLLLKAYSHKQQRLMEQPANVET 127
                    |.|::||.::||.|.:    ..|.|.:.   ..:..:.:....:.:||:.:|.. ..
Mouse   122 --------DPCQDFYSFACGGWLR----RHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTG-GP 173

  Fly   128 DEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPV---LSLPG-QEWPAEEFDWLDTV 188
            ...|..:::.|:.|||..|:: |.|..|.:.|::.|.|...:   ...|| ..|......:
Mouse   174 GGAAQRKVRAFFRSCLDMREI-ERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLY---- 233

  Fly   189 ARIKRQYGFDILLLFQQSA---DR------IYVGQPKQILPEANRKAVAED------------IA 232
               |.|..:....||..:.   ||      |.:.|....||| ....:|:|            ..
Mouse   234 ---KAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPE-RTLYLAQDEESEKILAAYRVFM 294

  Fly   233 NHLERHLGVDPKVAVTTAREITEFEQKIAAIMV----DRRVGVMSKLYTPSDADYVDVSKLTQFV 293
            ..|.|.||.|  .....|:||.:.||::|.|.|    |.|..|.|..      :.|.:.:|.:.:
Mouse   295 QRLLRLLGAD--AVEQKAQEILQLEQRLANISVSEYDDLRRDVSSAY------NKVTLGQLQKII 351

  Fly   294 ---------ETVLDRELLANESLYQHVPDYLMKIDELVTETPPHVLANYV--------------- 334
                     :.:...:....|.:.....||:.::.:|:..||..:|.||:
Mouse   352 PHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSP 416

  Fly   335 FNELLKHFYYE-----RAESVVEQCVSRVRDLFGELLDHMLFEQY-------EDEGTLKDI-YVV 386
            |.|.|.....|     :.:.:...|:.:....||..|..:...::       :.:..::|| |::
Mouse   417 FREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYIL 481

  Fly   387 WQQLQRSFRGVLQNSSANWLVPETREQLLEQLNTTSLVINGYAEV-----NFTQRYE-ELHLKP- 444
            .|:|:          ..:|:..:|:.....:|. ..:|:.||.:.     ...:.|| |:|.|.
Mouse   482 GQRLE----------ELDWMDAQTKAAARAKLQ-YMMVMVGYPDFLLKPEAVDKEYEFEVHEKTY 535

  Fly   445 -RDYLHNLRTILNHQSLRVKVKTQTS----------VTYDPVGKRVLLPVALLQPNFLWSRYYPK 498
             ::.|:::|..:.....:::.:...|          ..|.|...:::.|..:|||. |:...:|:
Mouse   536 FKNILNSIRFSIQLSVKKIRQEVDKSSWLLPPQALNAYYLPNKNQMVFPAGILQPT-LYDPDFPQ 599

  Fly   499 AVRYGSLGTLLAQQLAHSLED-----------ASKWDAKSFAEYSKRKSCFKEQYGRL-----RL 547
            ::.||.:||::..:|.|..:|           ...|...|::.:.::..|....|...     |:
Mouse   600 SLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRV 664

  Fly   548 NG-HYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLW 611
            || |.|      .|||||...:::||:||::.:.|..|    ...|.:|.....:|||::|||.|
Mouse   665 NGKHTL------GENIADMGGLKLAYYAYQKWVREHGP----EHPLHRLKYTHNQLFFIAFAQNW 719

  Fly   612 CNDANEQFRDKQSLFL------GTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            |..     |..||::|      ..|...||||::|.|..|||.|:|...|.|....||.::
Mouse   720 CIK-----RRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	157/699 (22%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	159/700 (23%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	159/720 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840