Protein Alignment Nepl19 and Nep2

DIOPT Version :10

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: XP_061497288.1
• Gene: Nep2 / 1281326
• VectorBaseID: AGAMI1_002834
• Length: 792
• Species: Anopheles gambiae
• Alignment Length: 700
• Identity: 166/700 - (23%)
• Similarity: 289/700 - (41%)
• Gaps: 121/700 - (17%)

  Fly    60 SKSAEMRSYMQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQQRLMEQPAN 124
            ||:.|.   |.|:.:.|::||:|:||.:.:    ....|.|    ::.:..:|....||.:|..:
Mosquito   121 SKALEQ---MDQEVEPCDDFYNYACGKFVK----ETVIPDE----KVSVNTFSVIGDRLQQQLRS 174

  Fly   125 VETDEVA-----VLRL-KEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAE-EF 182
            :.::|::     ..:| |..|..|:...:: |:...:.|.:|....|..|||.  |..|..: .:
Mosquito   175 LVSEEISDSEATPFKLAKNLYKLCMNKTRI-EEKGIKPLLDIHEVLGGWPVLK--GDSWDLDSSW 236

  Fly   183 DWLDTVARIKRQ-YGFDILLLFQQSAD------RIY------VGQPKQILPEANRKAVAEDIANH 234
            .|:.:|...:.. |..|....|...:|      ||.      :|..::.|.:.....:.....|:
Mosquito   237 SWVKSVKDFRNNGYSTDYFFDFSIGSDLKNSTRRIIDTDQASLGISREYLVKGMENPIVSAYYNY 301

  Fly   235 LERH---LGVDPKVAVTTAREITEFEQKIAAIMV--DRRVGVMSKLYTPSDAD-----YVDVSKL 289
            :...   ||.|.:.|.....:...||..:|.|.:  ::|... :.||.|....     |.....|
Mosquito   302 MVDMAVLLGADEERAKRELLDSLNFEMALANISLPNEKRRNA-TALYNPMTVKEFQQRYPYTDWL 365

  Fly   290 TQFVETVLDRELLANES--LYQHVPDYLMKIDELVTETPPHVLANYV-----------FNELL-- 339
            ..|...:.|..::..|.  :...||.::.::..|:..||..|:||||           ..|.|
Mosquito   366 EYFNAILKDTGIVIGEEEVIIVSVPTFMEQLGPLLQNTPKRVMANYVMWRISGFSSFFLTEKLRK 430

  Fly   340 KHFYYERA-------ESVVEQCVSRVRDLFGELLDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGV 397
            :...|..|       |...::||..........:..:...:|..|.:.:....:...::..|..:
Mosquito   431 RQLQYSTALSGKQEQEPRWKECVDITSGSLPISVGALYIRKYFREDSKRAALDMVNDIKSVFVDI 495

  Fly   398 LQNSSANWLVPETREQLLEQLNTTSLVINGYA-----EVNFTQRYEELHLKPRD-------YLHN 450
            |:  ..:|:...||...||:::|.:..| ||.     :....:.|::|..:|..       |::.
Mosquito   496 LK--KVDWMDEVTRVSALEKVSTMATHI-GYPDELMDDAKIAEYYKDLEFQPDSTYLNTILYMNK 557

  Fly   451 LRTILNHQSLRVKVKTQTSVT----------YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSL 505
            ..|....:.||:.|.....:|          |..:...:..|..:||..| :|...||.:.||::
Mosquito   558 FGTTKAFKKLRIAVNKTDWITHSRPAIVNAFYSSIENSIQFPAGILQGQF-FSYDRPKYMNYGAI 621

  Fly   506 GTLLAQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYG-------RLRLNGHYL 552
            |.::..::.|..:|..:           |.:.:...|.::..|..||||       :|.|||
Mosquito   622 GFVIGHEITHGFDDQGRQFDKNGNLVDWWQSDTKTAYLEKARCIIEQYGNYTEPNVKLNLNG--- 683

  Fly   553 PESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCNDAN- 616
              .:.|.||||||..|:.||:||||...:..|    .:.||.|||...::|:||.||.||:...
Mosquito   684 --INTQGENIADNGGIKEAYYAYRRWTEKNGP----EQRLPGLNLSPEQMFWLSAAQTWCSVYRP 742

  Fly   617 EQFRDKQSLFLGTPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            |..:.:.:..:.:|...||||.:||...|.:||||...|.|....||:::
Mosquito   743 ETMKMRITTGVHSPGQFRVLGPMSNMHEFAKDFNCPVGSPMNPEHKCEVW 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	M13	73..664	CDD:341056	160/683 (23%)
Nep2	XP_061497288.1	None