Protein Alignment Nepl19 and Ece2

DIOPT Version :10

• Sequence 1: NP_651644.1
• Gene: Nepl19 / 43411
• FlyBaseID: FBgn0039612
• Length: 671
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 695
• Identity: 168/695 - (24%)
• Similarity: 278/695 - (40%)
• Gaps: 136/695 - (19%)

  Fly    69 MQQDADACENFYDYSCGNWPQINPANDAYPRETNFVQLLLKAYSHKQ---QRLMEQPANVETDEV 130
            :.:....|::||.:|||.|.:.||..:...|...|..|    :...|   :.|:|......:.|
Mouse   108 LDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSL----WDQNQAILKHLLENTTFNSSSE- 167

  Fly   131 AVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPAEEFDWLDTVARIKRQY 195
            |..:.:.||.|||...:: |.|..:.|::::...|...:..      |.:|..::|.:..:...|
Mouse   168 AERKTRSFYLSCLQSERI-EKLGAKPLRDLIDKIGGWNITG------PWDEDSFMDVLKAVAGTY 225

  Fly   196 GFDILLLFQQSADR-------IYVGQPKQILPE--------ANRKAVAE--DIANHLERHLGVDP 243
            ..........|||.       |.|.|....||.        ||.|.:..  |....|...||..|
Mouse   226 RATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMVELGVLLGGQP 290

  Fly   244 KVAVTTAREITEFEQKIAAIMV--DRRVGVMSKLYTPSD-------ADYVDVSKLTQFVETVLDR 299
            .......:::.|.|.::|.|.|  |:|.. ..|:|....       |..||..:...|:.:.|
Mouse   291 TSTREQMQQVLELEIQLANITVPQDQRRD-EEKIYHKMSISELQALAPAVDWLEFLSFLLSPL-- 352

  Fly   300 ELLANESLYQHVPDYLMKIDELVTETPPHVLANYVF-------------------NELLKHFYYE 345
            ||..:|.:..:..:||.::.||:..|.|.:|.||:.                   .:||:..|..
Mouse   353 ELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGT 417

  Fly   346 RAESVV--EQCVSRVRDLFGELLDHMLFEQYED-------EGTLKDIYVVWQQLQRSFRGVLQNS 401
            :.....  :.|:|...|..|..|..:..:...|       ||.:.:|       :.:|...|  .
Mouse   418 KKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEI-------RSAFEETL--G 473

  Fly   402 SANWLVPETREQLLEQLNTTSLVINGYAEVNFTQR-----YEELHLKPRDYLHNLRTILNHQSLR 461
            ...|:..:||....|:.:....:| |:.:.....:     |:...:....:..|:   ||..:..
Mouse   474 DLVWMDEKTRLAAKEKADAIYDMI-GFPDFILEPKELDDVYDGYEVSEDSFFQNM---LNLYNFS 534

  Fly   462 VKV----------KTQTSVT-------YDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLL 509
            .||          :.|.|:|       |.|....::.|..:||..| ::..:|||:.:|.:|.::
Mouse   535 AKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF-YAHNHPKALNFGGIGVVM 598

  Fly   510 AQQLAHSLEDASK-----------WDAKSFAEYSKRKSCFKEQYGRLRLNGHYLPESDLQAENIA 563
            ..:|.|:.:|..:           |..:|...:....:|.:|||.:.::||..|.......||||
Mouse   599 GHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIA 663

  Fly   564 DNLAIQVAYHAYRRLLAELDPSFLGSES-LPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFL 627
            ||..::.||:||:..|.:     .|.|. ||.:.|.:.:|||:.|||:||:     .|..:|...
Mouse   664 DNGGLKAAYNAYKAWLRK-----HGEEQPLPAVGLTNHQLFFVGFAQVWCS-----VRTPESSHE 718

  Fly   628 G------TPNALRVLGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            |      :|...||||.|||.|.|.|.|.|...|.|...|.|:::
Mouse   719 GLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	M13	73..664	CDD:341056	167/687 (24%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	167/687 (24%)