DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and mme

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	746	Identity:	162/746 - (21%)
Similarity:	288/746 - (38%)	Gaps:	170/746 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SNDSAYVQRLMRLSKSAEMRSYMQQDADACENFYDYSCGNW------PQINPANDAYPRETNFVQ 105
            |||.....:.. :|.:|.:.:.|....|.|.:||.|:||.|      |..|..::.:......::
Frog    45 SNDGICTSQAC-ISTAARIIANMDAATDPCNDFYQYACGGWLKKNRIPDNNIVSNTFDILRTDIE 108

  Fly   106 LLLKAYSHKQQRLMEQPANVETDEV-AVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPV 169
            ::||....|:          ..|:: |:.::|.||.||:       |...:.|::     |...:
Frog   109 VVLKDALEKE----------SADDIPAIKKVKTFYKSCI-------DETIKNLRK-----GGPLI 151

  Fly   170 LSLPG-QEWPAEEFDW----------LDTVARIKRQYGFDILL-------LFQQSADRIYVGQPK 216
            .:||. .:||....:|          .:::|....:||...|:       |...|...:::.||.
Frog   152 KTLPALYDWPIAVDNWETRYGLVWSAQESIAGFITKYGQSGLINVYVSEDLTNSSTYILHIDQPG 216

  Fly   217 QILP-------------------------------EANRKAVAEDIANHLERHLGVDPKVAVTTA 250
            ..||                               |.|.....:.|.:.:|:...::.::|...|
Frog   217 LGLPSKDYYDCKGTSEIACLAYMEQMVSVAMLIRKERNLTINEDKILSEMEKVFKLEREIAKAEA 281

  Fly   251 REITEFEQKIAAIMVDRRVGVMSKLYTPSDADY-VDVSKLTQFVETVLDRELLANESLYQHVPDY 314
            .|  |..:.:..|.....:..::|.|.....|. ::..||...:.:.....:..||.:.....||
Frog   282 SE--EIRENLNDIYKKMTLSGIAKTYPLKMNDQNINWLKLINAIISPGGVSIEENEQVALICSDY 344

  Fly   315 LMKIDELVTETPPHVLANYV--------FNE-----------LLKHFYYERAE-SVVEQCVS--- 356
            |.|: ..:.:.....|.||:        .|:           |.|..|...|| |..:.||:
Frog   345 LKKL-RFLNKYKARELQNYLGWRYILSAINDLSLEYKNTGIHLKKALYGNAAEGSDWQTCVTYLN 408

  Fly   357 -RVRDLFGEL-LDHMLFEQYEDEGTLKDIYVVWQQLQRSFRGVLQNSSANWLVPETREQLLEQLN 419
             .:.|..|.| |...|....|.......:..:..:::|:|..:|:  ..:|:..:|:::...::.
Frog   409 DNMEDAIGRLYLKETLSADIEHVKVKDKVKEIIAEIRRAFLEMLE--EMDWMDEDTKKRAARKVA 471

  Fly   420 TTSLVI-------------NGYAEVNFTQRYEELHLKPRDYLHNLRTILNHQSLRVKVKTQT--- 468
            :.:..|             .||:|:.|  |.:||....:.|:..::..:..: ||.:|....
Frog   472 SINERIAFSEDIMDDFKLNEGYSELEF--RVDELFENKQKYIEFVQKKMTSR-LRKQVNKNEWVP 533

  Fly   469 ---------SVTYDPVGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLED----- 519
                     |:||:    .::.|..:||..| :|...|.|:.||.:|.::..::.|..::
Frog   534 GPAHVNAFYSLTYN----EIVFPAGILQTPF-FSSSQPSALNYGGIGMIIGHEITHGFDNRGCNF 593

  Fly   520 ------ASKWDAKSFAEYSKRKSCFKEQYGRL---RLNGHYLPESDLQAENIADNLAIQVAYHAY 575
                  .:.|...|...:|....||..|||..   ...|.||.......|||:||..|:.||.|:
Frog   594 DEHGNLVNWWTNASMMNFSNLSQCFVNQYGNYSWDEAGGQYLNGISTLGENISDNGGIRGAYRAF 658

  Fly   576 RRLLAELDPSFLGSESLPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFL-----GTPNALRV 635
            :..:    .|....:.||.::|.|.:|||:||.|:||.    ..|.:.:..|     .||...||
Frog   659 KNYV----KSHKEDDLLPGIDLDSDQLFFISFGQIWCG----MHRPEYAATLIKTGSHTPGIFRV 715

  Fly   636 LGALSNFRAFGRDFNCGTASRMTSPQKCQLF 666
            :|.|.|...|.:.|:|...:.|....||:|:
Frog   716 IGTLQNSPEFSKAFSCCNNAYMNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	153/715 (21%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	154/716 (22%)
mme	XP_031758820.1	M13	71..744	CDD:341056	154/715 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020