DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl19 and ecel1

DIOPT Version :9

Sequence 1:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_012818808.2	Gene:	ecel1 / 100496473	XenbaseID:	XB-GENE-989944	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	733	Identity:	170/733 - (23%)
Similarity:	299/733 - (40%)	Gaps:	190/733 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 MRLSKSAEMRSYMQQDAD----ACENFYDYSCGNWPQINPANDAYPRET---NFVQLLLKAYSHK 114
            ||.||      ::..:.|    .|.:||.::||.|.:    ....|.:.   ..:..:.:....|
Frog    99 MRASK------FITNNIDPTISPCTDFYSFACGGWLR----RHGIPEDKLIYGTIAAIGEQNEEK 153

  Fly   115 QQRLMEQPANVETDEVAVLRLKEFYASCLLFRQVPEDLYRRQLQEIVADFGRMPVLSLPGQEWPA 179
            .:.|:.||...:....|..::|||:.|||..|.: :.|..|.:.:::.|.|..   .||  |.|.
Frog   154 LEHLLLQPVRRKHKGSAERKVKEFFKSCLNMRDI-DRLGARPMLQVIEDCGGW---DLP--EDPR 212

  Fly   180 EEFDWLDTVARIKRQYGFDILLLFQQSAD---------------------RIYVGQPKQ------ 217
            .::|:.:.:.:.:..|...:......|.|                     .:|:||.::
Frog   213 TQWDFNELLYKTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQDGLTLPERTLYLGQDEESIKVLE 277

  Fly   218 -----------ILPEANRKAVAEDIANHLERHLGVDPKVAVTTAREITEFEQKIAAIMVDRRVGV 271
                       :|...|.:..||:|. |||:||.     .:|    |:||:        |.|..:
Frog   278 AYKVFMQTILSLLGVENVQKKAEEIL-HLEQHLS-----NIT----ISEFD--------DMRRDI 324

  Fly   272 MSKLYTPSDADYVDVSKLTQFVETVLDRELLANESLYQHVP----------DYLMKIDELVTETP 326
             |.:|     :.|.:::|.| :...|:.:.|.|...:.:.|          ||:.|:.|::..||
Frog   325 -STMY-----NKVTLAQLQQ-ITPHLNWKNLLNRIFHTNFPEDEEVVVLATDYMQKVSEMIRSTP 382

  Fly   327 PHVLANYV-------------------FNELLKHFY-YERAESVVEQCVSRVRDLFGELLDHMLF 371
            ..||.||:                   .:||.|... .|:...:.:.|:::....||..|..:..
Frog   383 ASVLHNYMLWRIVVVLSEHLSTPFRDAIHELSKEMEGSEKQAELTKVCLTQANKHFGMALGALFV 447

  Fly   372 EQYEDEGTLKDIYVVWQQLQRSFRGVL--QNSSANWLVPETREQLLEQLNTTSLVINGYAEV--- 431
            |:|....:...:    |||..:.:.:|  :....:|:..||::...|:|....::| ||.:|
Frog   448 EEYFSSSSKAKV----QQLVENIKHILDYRLEELDWMDTETKQAAREKLKHMMVMI-GYPDVLLQ 507

  Fly   432 --NFTQRYEELHLKPRDYLHNLRTILNHQSLRVKVKTQT-------------------SVTYDPV 475
              :..:.| |..:..:.|..|   |||  |:|..:|...                   :..|.|.
Frog   508 PESMDKEY-EFEVNEKTYFKN---ILN--SIRYSIKMAVRRIRQEVDKSAWLLPPQALNAYYLPN 566

  Fly   476 GKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLED-----------ASKWDAKSFA 529
            ..:::.|..:|||. |:...:|:::.||.:||::..:|.|..:|           ...|...|::
Frog   567 KNQMVFPAGILQPT-LYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDANGNPIQWWTEDSYS 630

  Fly   530 EYSKRKSCFKEQYGRL-----RLNGHYLPESDLQAENIADNLAIQVAYHAYRRLLAELDPSFLGS 589
            ::.|:..|..:.|...     |:||.     ....|||||...:::||:||::.:.:..|    .
Frog   631 KFLKKAECIVDLYENFTVYNQRVNGR-----TTLGENIADLGGLKLAYYAYQKWVRDNGP----E 686

  Fly   590 ESLPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFL------GTPNALRVLGALSNFRAFGRD 648
            ..||:|.....:|||::|||.||..     |..||::|      ..|...||:|::|.|..|||.
Frog   687 RPLPRLKYTHDQLFFIAFAQNWCIK-----RRSQSIYLQVLTDKHAPEHYRVMGSVSQFEEFGRV 746

  Fly   649 FNCGTASRMTSPQKCQLF 666
            |:|...|.|....||.::
Frog   747 FHCPRNSPMNPVHKCSVW 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	163/712 (23%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	165/713 (23%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	164/709 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020