DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and ece2b

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	782	Identity:	199/782 - (25%)
Similarity:	316/782 - (40%)	Gaps:	189/782 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LCLLVAIVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYTHACGNWH 73
            :||..|.|...:|..:|.|..||                            ||.|||.:|||.|.
Zfish    94 ICLTEACVTVASKIVEALDRSAD----------------------------PCQDFYQYACGGWV 130

  Fly    74 RHNPAQLLGDVMT--DNFKLISKGFDRRLQRLLRAN--DLQSELEKKMQRFYMSCNLVHRDDVHY 134
            |.||   |.|..:  ..|..|.......|:.||...  :..||.|:|.|.:|:||
Zfish   131 RKNP---LPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAERKTQSYYLSC---------- 182

  Fly   135 KLALENVIREYGTLPAL-----VGAQWNSSDFSWWR-----TVAQIQHKYGKQIIIGLEIMHDIR 189
              ..|..|.|.|..|.:     :|. ||.:: ||.:     .:..|...|..|....:.:..|.:
Zfish   183 --LNEQRIEELGAQPLMDLITKIGG-WNITE-SWDKENFLDVLKIISGPYRAQPFFTVSVSVDPK 243

  Fly   190 NTSVNRV--------------YISQPDFKTINTRLTNLME--------EVRTSMDLQQYFGLSSS 232
            |::.|.:              |:::.:.|.:...|..::|        :..|...:||.....::
Zfish   244 NSNSNVIQVDQSGLFLPSRDYYLNKTNEKVLKAYLDYMVELGLLLGGDKNSTRGQMQQILDFETA 308

  Fly   233 VAKHTAEQLTELERTFSSGGSGAATLQESLSLY---TVADLQEKYSDHLNFTEFLGLILG--EEN 292
            :|..|..|   .||            ::...:|   |:|||| ..:..:.:.::|..:|.  |.|
Zfish   309 LANITVPQ---DER------------RDEEKIYHKITIADLQ-VLAPAIEWLDYLNSVLSPLELN 357

  Fly   293 IPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKL-------LEDFLVDAQPKDM--------- 341
            ..:.:.:|.:||:.:....:..|..:...||::|.|       |:....:||.|.:
Zfish   358 DTEPVVVYAKEYMQQVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFENAQDKLLESLYGTKKS 422

  Fly   342 --VKW--C---TESTKKY-FGKLAEHAVYKRY----------------RNPDVESEVHKIW---- 378
              .:|  |   |:.|..: .|.|...|.:.:.                ||  |.|.||.:.
Zfish   423 CTPRWQTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGRN--VNSTVHNLMFSVI 485

  Fly   379 -------DQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNIN----SYDEENFENVYGEVF 432
                   ::|:..|:..|  |.|.|:...||..|.:|.:.::..|.    ..|.:..::||....
Zfish   486 TQAEGMINEIRTAFKGAL--DDLKWMDEQTRQAAKDKADAIYDMIGFPDFILDSKELDDVYDGYE 548

  Fly   433 IDRLNYVSNVQQLLIAKGIRFVARINQPADSV---DATELLGFTPA-----YNIQENNITIPVAL 489
            :...|:..|:...     ..|.||:  .||.:   ...:....||.     |...:|.|..|..:
Zfish   549 VTEDNFFQNMINF-----YNFSARV--MADQLRKPPNRDQWSMTPPTVNAYYMPTKNGIVFPAGI 606

  Fly   490 LQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQ 554
            ||.. |:...:|:||.:..:|.::.||:.|.|||.||:||..|||..||...|...|:.|.:|..
Zfish   607 LQAP-FYAQDHPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWQNSSVEAFKNRTECMV 670

  Fly   555 AQYHEYQYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFF 619
            .||.:|...|..:...:...|||||:||||.||.||..|:.:..||    :.:..:...:.||||
Zfish   671 DQYTQYTINGEHINGKQTLGENIADNGGLKAAYHAYRSWVQKNGEE----KRLPAVNLTNDQLFF 731

  Fly   620 LGYAQLLCDDVQFLFQPWVS----QSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCA 680
            :|:||:.|.    :..|..:    .:|.|:|.||||||.|||..||...|.|...:.|:..::|.
Zfish   732 VGFAQVWCS----VRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSGHRCE 792

  Fly   681 IY 682
            ::
Zfish   793 VW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	190/735 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	189/728 (26%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950