Protein Alignment Nepl18 and MMEL1

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 190/739 - (25%)
• Similarity: 319/739 - (43%)
• Gaps: 151/739 - (20%)

  Fly    41 IIVQAKVAEMKTMMKPEVSPCDDFYTHACGNW-HRH-----NPAQLLGDVMTDNFKLISKGFDRR 99
            :|..|::.:   .|.|...||||||..|||.| .||     |....:.||:.|..::|.|..
Human    95 VIAAARILQ---NMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAV--- 153

  Fly   100 LQRLLRANDLQSELEK------KMQRFYMSCNLVHRDDVHYKLALENVIREYGTLPAL-----VG 153
                     |::...|      |.:..|.||            ..::||.:.|:.|.|     ||
Human   154 ---------LENSTAKDRPAVEKARTLYRSC------------MNQSVIEKRGSQPLLDILEVVG 197

  Fly   154 A------QWNSSDFSWW---RTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDF------ 203
            .      :||.:....|   |.:|.:..::.::::|.|.|.:|.:|:|.:.:||.||..
Human   198 GWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSRE 262

  Fly   204 --------KTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQE 260
                    :.:.......|..|.|.:.........|.:.:....|:.|||...:..........:
Human   263 YYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHD 327

  Fly   261 SLSLYTVADLQEKYSDH----LNFTEFLGLILGEENI----PKSLYIYDEEYLDKALLTMRSTPL 317
            .::||....|:|..|..    .|:|.|:..:|....|    .:.:.:|...||......:.:...
Human   328 VIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSA 392

  Fly   318 ATQANYVLWKLLEDFL--VDAQPKDM---------------VKW--CTESTKKYFGKLAEHAV-- 361
            .|..||::|:|:.|.:  :..:.||.               |:|  |.    .|.....|:||
Human   393 RTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECV----GYVNSNMENAVGS 453

  Fly   362 -YKRYRNP-DVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEK--------------LE 410
             |.|...| |.:|.|.::.|:::.:|.:.|  |:|.|:...::..|.||              ||
Human   454 LYVREAFPGDSKSMVRELIDKVRTVFVETL--DELGWMDEESKKKAQEKAMSIREQIGHPDYILE 516

  Fly   411 RMHLNINSYDEENFENVYGEVFIDRLNYVSNVQQLLIAKGIRFVARINQPADS----VDATELLG 471
            .|:..:    :|.:.|:.   |.:.|.:.:::|.|.:. ..|.:.::.:..|.    :.|..:..
Human   517 EMNRRL----DEEYSNLN---FSEDLYFENSLQNLKVG-AQRSLRKLREKVDPNLWIIGAAVVNA 573

  Fly   472 FTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAP 536
            |   |:...|.|..|..:|||.:|..:| |:||.:..:|.::.||:.|||||:||.:|.:||:..
Human   574 F---YSPNRNQIVFPAGILQPPFFSKEQ-PQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMD 634

  Fly   537 WWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQS--------ENIADSGGLKLAYAAYELW 593
            ||...|...|.|:.:|.     .||||......:.:|:        |||||:||::.||.||..|
Human   635 WWSNFSTQHFREQSECM-----IYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKW 694

  Fly   594 LGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNF 658
            :.:..::    :.:.||.....||||:.|||:.|...:..|.....::|.|:|.||||:|.|.|.
Human   695 MAEGGKD----QQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNL 755

  Fly   659 QEFPWVFNCSQSAPMDPEYKCAIY 682
            ..|...|:|::..||.|:.:|.::
Human   756 AAFADTFHCARGTPMHPKERCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	185/717 (26%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	185/716 (26%)