DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and PHEX

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	752	Identity:	179/752 - (23%)
Similarity:	309/752 - (41%)	Gaps:	185/752 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AEMKTMMKPE---------------VSPCDDFYTHACGNWHRHNPAQLLGDVMTDN-FKLISKGF 96
            |:.:..:|||               |.|||:|:..||..|..:||  :..|:.:.. :..:....
Human    49 AKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNP--IPEDMPSYGVYPWLRHNV 111

  Fly    97 DRRLQRLL-----RANDLQSELEKKMQRFYMSC---NLVHRDDVHYKLALENVIR----EYGTLP 149
            |.:|:.||     |..|  :|..:|.:..|.||   ..:.:.|..   .|.:::|    .:..|.
Human   112 DLKLKELLEKSISRRRD--TEAIQKAKILYSSCMNEKAIEKADAK---PLLHILRHSPFRWPVLE 171

  Fly   150 ALVGAQ--WNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTN 212
            :.:|.:  |:...||..:|:|..:.:|...:.|              |:|:| ||.|..|..:..
Human   172 SNIGPEGVWSERKFSLLQTLATFRGQYSNSVFI--------------RLYVS-PDDKASNEHILK 221

  Fly   213 LME----------------EVRTSMDLQQYF--------GLSSSVAKHTAEQLTELE-------- 245
            |.:                |.::..|....|        |.:||.|:|..:.:..||
Human   222 LDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMI 286

  Fly   246 ----RTFSSGGSGAATLQESLSLYTVADLQEKYSDHLNFTEFLGLI-----------LGEENIPK 295
                ||             |.::|...::.| .|..:...::||.|           |.:.:..:
Human   287 PHENRT-------------SEAMYNKMNISE-LSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSE 337

  Fly   296 SLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDFLVDAQPKDMVKW---------------- 344
            ::.:...:|.......:.|....|.|||::|:::...:.:...:...:|
Human   338 NVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQ 402

  Fly   345 ---CT---ESTKKY-FGKLAEHAVYKRYRNPDVESEVHKI-WDQIKGIFRQRLLGDKLDWISNAT 401
               |.   ||...| .||:.....::..:...:|..|..: |..|.      :|..:.:|:...|
Human   403 WDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFID------MLEKENEWMDAGT 461

  Fly   402 RTLAIEK--------------LERMHLNIN----SYDEENFENVYGEVFIDRLNYVSNVQQLLIA 448
            :..|.||              :...|:|.:    .:.|.::   :|.|...| .|::......:.
Human   462 KRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADY---FGNVLQTR-KYLAQSDFFWLR 522

  Fly   449 KGIRFVARINQPADSVDATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLL 513
            |.:........|. :|:|        .|:...|.|..|...||..:|||.:||.:|.|..:|.::
Human   523 KAVPKTEWFTNPT-TVNA--------FYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIV 578

  Fly   514 AHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQY--GGSKLPESKDQSEN 576
            .||..||||::||:||.:|||.|||..:|..:|:|:.||...||..|.:  .|..:...:...||
Human   579 GHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGEN 643

  Fly   577 IADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVS-- 639
            |||:|||:.|:.||..|:..: .:.|:...:.|:.|.:.|||||.||.:.|:.    ::|..:
Human   644 IADNGGLREAFRAYRKWINDR-RQGLEEPLLPGITFTNNQLFFLSYAHVRCNS----YRPEAARE 703

  Fly   640 --QSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMD 674
              |...|:|.::||.|.:|||:||...|||..::.|:
Human   704 QVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	178/746 (24%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	175/727 (24%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	175/727 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920