Protein Alignment Nepl18 and Nep5

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Alignment Length: 794
• Identity: 181/794 - (22%)
• Similarity: 314/794 - (39%)
• Gaps: 222/794 - (27%)

  Fly    54 MKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDN--FKLISKGFDRRLQRLLRANDLQSELE-- 114
            |..:..||:|||...||.|...:|..   |.:|.|  |:.......|.::..||:|..:||.|
  Fly   146 MDEQTDPCEDFYQFTCGRWANEHPRP---DSVTSNDWFRERQAHIMRVVREFLRSNITKSEPEAV 207

  Fly   115 ---KKMQRFYMSCNLVHRDDVHYKLALENVIREYG--TLPALVGAQWNSSD----------FSWW 164
               |.|.|..|...|:.:.|:.   .|.|.:..:|  .||:.:.....|..          ::|.
  Fly   208 GKAKTMYRACMDTKLLDKRDLE---PLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWL 269

  Fly   165 RTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDF--------------------KTI--- 206
            :::..|:......:|||.::..|..|.::||:.:..|:.                    |||
  Fly   270 QSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQ 334

  Fly   207 -----------------------NTRLTNLMEEVRTSMDLQQY--------------FGLSSSVA 234
                                   :|.:|..:..||..  :::|              .|::..|.
  Fly   335 NSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKV--IEKYLLYVDPNVNQEEATLGITELVK 397

  Fly   235 K--HTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYSDHLN------FTEFLGLIL--- 288
            :  ..|.::.|.:....:....:....:.:...|:.|||.:...::.      :..::.|||
  Fly   398 QGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPIWVRYMELILKGT 462

  Fly   289 ---GEENIPKSLYIY----DEEYLDKALLTMRSTPLATQANYVLWKLLEDFLV------------ 334
               |...:.::|.|.    |..||...:..:..||.:...:|:....:|:.::
  Fly   463 RHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSE 527

  Fly   335 ---------DAQPKDMVKWCTESTKKYFGKLAEH----AVYKRYRNPDVE---SEVHKIWDQIKG 383
                     .:.|:.:  :|........|....:    |.:.:.:.|.||   |::.:.:|:
  Fly   528 YMRVAIGTEGSTPRSL--YCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDR--- 587

  Fly   384 IFRQRLLGDKLDWISNATRTLAIEKLERMHLNI------------NSYDE-------ENFENVYG 429
                  |.....|:..||:...|:|...|...|            |:|.|       .:.||:..
  Fly   588 ------LVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMD 646

  Fly   430 EV---FIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATELLGFTPA-------YNIQENNIT 484
            .|   .:|:||                         .:|..|.:|:..:       :..|.|.||
  Fly   647 FVHWQMMDKLN-------------------------EMDKPEPIGWATSPSNVNAFHTFQSNAIT 686

  Fly   485 IPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEER 549
            :|:|:||  |.:.|...|||.|.::|.:|.||:.|||||.||::|.:||:..||..::..|:..|
  Fly   687 VPIAILQ--YPFYDLGLEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNR 749

  Fly   550 RKCFQAQYHEY------QYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETME 608
            .:||..||..|      :|...:|    ...|||||:||::.|:.||.|::.:...|   |..:.
  Fly   750 TECFVEQYSRYHLADIDEYIDGEL----TLGENIADNGGMREAFYAYRLYVKEVGRE---RSKLP 807

  Fly   609 GLP-FNSRQLFFLGYAQLLCDDVQFLFQPWVSQ---SDRHAPSKYRVIGPLSNFQEFPWVFNCSQ 669
            ||. ::..||||:.:..|.|:    .:.|..|:   :|.|.|.:.|:.|.|||.:||...|.|::
  Fly   808 GLEHYSHEQLFFISFGNLWCE----TYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCAR 868

  Fly   670 SAPMDPEY-KCAIY 682
            ..||:|:. ||.|:
  Fly   869 GTPMNPDQPKCRIW 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	177/785 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:341056	178/785 (23%)