DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and MME

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	787	Identity:	210/787 - (26%)
Similarity:	339/787 - (43%)	Gaps:	181/787 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLWLCLLVAIVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYTHACG 70
            ||.|.::...:.|:....|.|...:.|.....|:.|          ..|.....||.||:.:|||
Human    35 VLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLI----------QNMDATTEPCTDFFKYACG 89

  Fly    71 NWHRHN----PAQLLG--DVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFYMSC----- 124
            .|.:.|    .:...|  |::.|..:::.|..   ||. .:..|:.:  .:|.:..|.||
Human    90 GWLKRNVIPETSSRYGNFDILRDELEVVLKDV---LQE-PKTEDIVA--VQKAKALYRSCINESA 148

  Fly   125 --------NLVHRDDVH-YKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQIII 180
                    .|....|:: :.:|.||..::|       ||.|.:.     :.:||:..||||:::|
Human   149 IDSRGGEPLLKLLPDIYGWPVATENWEQKY-------GASWTAE-----KAIAQLNSKYGKKVLI 201

  Fly   181 GLEIMHDIRNTSVNRV-YISQP------------------------DFKTINTRLTNLMEEVRTS 220
            .|.:..|.:| |||.| :|.||                        ||.....||  :.:|.|..
Human   202 NLFVGTDDKN-SVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARL--IRQEERLP 263

  Fly   221 MDLQQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLY---TVADLQEKYSDHLN--- 279
            :|..|   |:..:.|     :.|||:..::..:......:.:.||   |:|.:|..:|..:|
Human   264 IDENQ---LALEMNK-----VMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKP 320

  Fly   280 --FTEFLGLILGEENI----PKSLYIYDEEYLDKALLTMRSTPLATQ------ANYVLWKLLEDF 332
              :..|...|:...||    .:.:.:|..|||.|.      .|:.|:      .|.:.|:.:.|
Human   321 FSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKL------KPILTKYSARDLQNLMSWRFIMD- 378

  Fly   333 LVDAQPKDMVKWCTESTKKYFGKLAEHAVYKR---YRNPDVESEV--------------HKIWD- 379
            ||.:..:...:......|..:|..:|.|.::|   |.|.::|:.|              |.:.|
Human   379 LVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDL 443

  Fly   380 --QIKGIFRQRLLGDKLDWISNAT------RTLAIE--------------KLERMHLNINSYDEE 422
              ||:.:|.|.|  |.|.|:...|      :.|||:              ||...:|.:|..::|
Human   444 IAQIREVFIQTL--DDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDE 506

  Fly   423 NFENVYGEVFIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATELLG----FTPAYNIQENNI 483
            .|||:     |..|.: |..:||   |.:|         :.||..|.:.    ....|:...|.|
Human   507 YFENI-----IQNLKF-SQSKQL---KKLR---------EKVDKDEWISGAAVVNAFYSSGRNQI 553

  Fly   484 TIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEE 548
            ..|..:|||.:| ..|...:|.|..:|.::.||:.|||||:||.::..|:|..||..:|...|:|
Human   554 VFPAGILQPPFF-SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617

  Fly   549 RRKCFQAQYHEYQY---GGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGL 610
            :.:|...||..:.:   ||..|.......|||||:|||..||.||:.::.:..||.|    :.||
Human   618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKL----LPGL 678

  Fly   611 PFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDP 675
            ..|.:|||||.:||:.|...:..:.....::|.|:|..:|:||.|.|..||...|:|.:::.|:|
Human   679 DLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNP 743

  Fly   676 EYKCAIY 682
            |.||.::
Human   744 EKKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	201/737 (27%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	198/730 (27%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	199/729 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150935
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800