DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and Nepl16

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001097912.1	Gene:	Nepl16 / 43014	FlyBaseID:	FBgn0039277	Length:	752	Species:	Drosophila melanogaster

Alignment Length:	754	Identity:	151/754 - (20%)
Similarity:	269/754 - (35%)	Gaps:	238/754 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYTHAC------------ 69
            ||::.|.:..||..:.:.|.      :||::...|       .||.:|...:|
  Fly   147 PAVSAPPECSDPICEAVASS------IQARLNWNK-------DPCTEFKKFSCWRNTPNKNITNL 198

  Fly    70 ---GNWHRHNPAQLL----GDVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFYMSCNLV 127
               ||..:...:|:|    ..:|..:|.::...|:..||        |:.....|.|.:.|..
  Fly   199 IEMGNSQKSVDSQMLYLFQNKIMNGSFGILHNLFESCLQ--------QTTNSTVMHRIFDSLG-- 253

  Fly   128 HRDDVHYKLALENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTS 192
                              |.||  ||:...||...   .:|:| :..|...::  ::.||:   |
  Fly   254 ------------------GYLP--VGSVGPSSIAP---LIAKI-YDLGPSPLV--DLYHDL---S 289

  Fly   193 VNR-----VYISQPDFKTINTRLTNLMEEVRTSMD------------------LQQYFGLSSSVA 234
            ..|     :.||.|     :|..|.|..::|....                  ::.:.....|.|
  Fly   290 YGRRPHILLIISGP-----STSSTILERKIRWMSPKAPPSRIRQGVPKLLADLIENFLPYFVSYA 349

  Fly   235 KHTAEQ---------LTELERTFSSGGSGAATLQESLSLYTVADLQEKYSDHLNFTEFLGLILGE 290
            :..:|:         |.:|:...|..|     ..:|..||.|:.||:.| ..||:|     :|..
  Fly   350 QRVSEKDTIFEFIKDLNKLQVEHSRRG-----FWDSTVLYNVSSLQDLY-PVLNWT-----LLIP 403

  Fly   291 ENIPKSLYIYDEEYLDKAL---LTMRSTPLATQANYVLWKLLEDFLVDAQPKD--MVKWCTESTK 350
            :|....:.:.:.:|| |||   ||...|.:|..:..:|..|      ...|:|  ..:.||.||.
  Fly   404 QNWSGPIVVRNSDYL-KALEYFLTKYPTRVAHNSLLLLSAL------QILPRDYPSPEVCTRSTM 461

  Fly   351 KYFGKLAEHAVYKRYRNPDVESEVHK---IWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERM 412
            ....:|:......::.:.|::....:   |:..:|...::          :.:.:..|:.||..
  Fly   462 WALPELSSSLYIAQHSSEDLKDTTKRAEIIFKSLKAHLKR----------APSLKGAALVKLSA- 515

  Fly   413 HLNINSYDEENFENVYGEVFIDRLNYVSNVQQLLIA-----KGIRFVARIN--QPAD------SV 464
             |.|.|...|.|.|.        .:.:.::|.|.|.     :.|..:.:.|  :|.|      |.
  Fly   516 -LKIQSQTWEGFSNT--------TDLLKSLQPLNITSECWFQNILEIYKKNKLEPNDISLNGGSH 571

  Fly   465 DATEL-LGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQY 528
            ||... :..|..|:...::|.:|::::...|| ....|..|.||::|..:|.|:|....   :.:
  Fly   572 DAWAYPIVSTIFYDTLSHSIVVPLSVILIPYF-NAVLPPYLHYASVGVSIAKEILRSIT---KSF 632

  Fly   529 DASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSEN------IADSGGLKLAY 587
            |                 |:..:|              :|.|.:...|      :..|||::::|
  Fly   633 D-----------------EKAMRC--------------VPHSVNIFSNYSRMDILIHSGGMQISY 666

  Fly   588 AAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVI 652
            .:.....|    .:.....:.||.....|:|||..||.||.:..:|      ..|.:||....::
  Fly   667 HSMLSLTG----PIKGMARLPGLNLTPTQIFFLVSAQELCAESNYL------GIDTNAPEFDNIL 721

  Fly   653 GPLSNFQEFPW----------VFNCSQSAPMDPEYKCAI 681
            |         |          ||.|...:.::.:..|.:
  Fly   722 G---------WLVAQGGSATEVFKCPSGSMINVQKTCNV 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	142/717 (20%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	141/709 (20%)
Nepl16	NP_001097912.1	GluZincin	176..749	CDD:301352	141/708 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910