DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and Nepl14

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	192/742 - (25%)
Similarity:	326/742 - (43%)	Gaps:	114/742 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSRVLWLCLLVAIVP-AMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDFYT 66
            |:..|||..|..:.. |:....|...||.....|:   :.:.::|..:|.:.:...:.||.|||.
  Fly     7 TTVFLWLLWLPHLQQNALVSGEDLPPPFQRIYQSE---QTVRRSKAQDMGSHVNKSIDPCVDFYA 68

  Fly    67 HACGNWHRH-NPAQLLGDVMTDNFKLISKGFDRRLQRLLRANDLQSELEKKMQRFYMSCNLVH-- 128
            :|||||... .|.|.| ...||...|:      .::..:|..|  |.:.::.:..:.||....
  Fly    69 YACGNWKSTLTPQQQL-QQQTDRELLL------LVEEAVRRED--SVIVRQAKELFKSCVSAQAH 124

  Fly   129 --RDDVHYKLALENVIREYGTLPALVGAQW--NSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIR 189
              :...|:   |...|.:.|..||:.|:||  :..|::|...:..::.:||..|:|||.:.::..
  Fly   125 QSQQQQHF---LSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIGLRVGYNYG 186

  Fly   190 NTSVNRVYISQPDFKTINTRL-TNLMEEVRTSM----------DLQQYFGLSSSVAKHTAEQLTE 243
            |.:.|.:|:|:|. ..|.|.| |....::|.|:          :|:.:..|....:...|..:..
  Fly   187 NVNENSLYLSEPS-TLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDESARLAADILS 250

  Fly   244 LERTFSSGGSGAA----TLQESLSL--YTVADLQE-KYSDHLNFTEFLGLILGEENIPKSLYIYD 301
            .|.....|..|.:    ..:|.|.|  ||...|:| ..|..|:...::....|:: |.|.:|:..
  Fly   251 FEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRASFGQD-IYKPVYMAA 314

  Fly   302 EEYLDKALLTMRSTPLATQANYVLWKLLE--DFLVDAQPKDMVKWCTESTKKYFGKLAEHAVYKR 364
            .||..:...|:.:..::..|||::::.:.  :|.:|.:|:...:.|.|.||:...........::
  Fly   315 PEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDRPQLRKRECLERTKELLPTALGELYARQ 379

  Fly   365 YRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYDEENFENVYG 429
            :...|...::..::|.:|...||.|   ..:|:...|:.:..|||..:.|.:.:|:..    |..
  Fly   380 FGTEDGRIDLDNLYDTLKTALRQSL---GAEWLVEGTQRVGQEKLRNLKLQMPTYERP----VIL 437

  Fly   430 EVFIDRLNYVSNVQQLLIAKGIRFVARINQ--------PADSVDATEL-LGFTPAYNIQENNITI 485
            ::.::|.||..|::|||   |:....|.|:        |.|.|:|.|. :...|.    :..:.:
  Fly   438 KLQLERGNYWQNLRQLL---GVVQSQRNNRLFEEFLPAPTDPVEAYEARVRLRPV----QRRLDM 495

  Fly   486 PVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPW---------WDLK 541
            .:|||||..: ..:|..|::|||||..||.:::..|||           ..|         ||.:
  Fly   496 GLALLQPPAY-DPRYGHAIRYATLGVQLAQQLVMAFDD-----------PHWSVGLLERDNWDGQ 548

  Fly   542 SRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEE----VL 602
            :.:::..|..||..|...|     ..|.....::.|.||..:.:|:.||..|||.|...    .|
  Fly   549 TAWQYHIRSNCFARQVDNY-----LRPNVSATTQLITDSAAINVAFRAYLTWLGFQEPNNDFTKL 608

  Fly   603 QRETMEGLPFNSRQLFFLGYAQLLCD-------DVQ-----FLFQPWVSQSDRHAPSKYRVIGPL 655
            .:||:..|.:::..||||.|||..|.       |.|     :|:    |....|..::..|.|||
  Fly   609 TKETLPDLNYSNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLY----SARQNHTWTRLLVNGPL 669

  Fly   656 SNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            .|..||...|.|...:||:|..||.||
  Fly   670 RNSVEFASEFRCPIGSPMNPASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	178/688 (26%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	176/681 (26%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	176/681 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850