Protein Alignment Nepl18 and Nep4

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_650904.3
• Gene: Nep4 / 42449
• FlyBaseID: FBgn0038818
• Length: 1040
• Species: Drosophila melanogaster
• Alignment Length: 826
• Identity: 209/826 - (25%)
• Similarity: 320/826 - (38%)
• Gaps: 230/826 - (27%)

  Fly    42 IVQAKVAEMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRA 106
            :.|||.  ||..|..:|.||.|||.:|||||.|.:|.. ......|.|:::.:..|..|:.||..
  Fly   260 MTQAKT--MKRYMDNKVDPCVDFYKYACGNWERLHPIP-KDKAGFDTFEMLRESLDLVLRNLLEK 321

  Fly   107 N-------------------------------DLQSEL-EKKMQRFYMS-CNLVHRDDVHYK--- 135
            |                               |..:|| .::::|..:| ..|::|..|.||
  Fly   322 NTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYT 386

  Fly   136 ----------------------------------------------------------------- 135
                                                                             
  Fly   387 NGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRS 451

  Fly   136 ------LA------LENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDI 188
                  ||      |..:|||.|..|.| .:||:.|:|: |:.:|....:|...|:|...:..||
  Fly   452 CVNSAVLAKRGLEPLHTLIRELGGWPVL-ESQWSESNFN-WQVLAATLRRYNNDILIVQWVGADI 514

  Fly   189 RNTSVN-------------RVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQ 240
            :|:..|             |.|..||............|.||...|      |.|.:.|:..|.:
  Fly   515 KNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKM------GASKADAQRVASE 573

  Fly   241 LTELERTFSSGGSGAATLQESLSLY---TVADLQ--------EKYSDHLNFTEFLGLILGEENIP 294
            |...|...:...:.|........||   |:..||        ..|...|...|    :||.|.:
  Fly   574 LVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDRE----VLGTEEV- 633

  Fly   295 KSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDFL--VDAQPKDM---------------V 342
               .||..||:.|.:..:..|...|.:||::|:.:...:  ||.:..|:               .
  Fly   634 ---VIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQ 695

  Fly   343 KW--CTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLA 405
            :|  |........|.........||.:.:.:.:..::...::..||..|  ...||:.:.|:.||
  Fly   696 RWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDIL--KTTDWLDDTTKQLA 758

  Fly   406 IEKLERMHLNI------------NS-------YDEENFENVYGEVFIDRLNYVSNVQQLLIAKGI 451
            .||:..|.|.|            ||       |.|:.|||.     ::.|.:.:..:|..:.:
  Fly   759 EEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENT-----LNVLLHTAKTEQAKLHE-- 816

  Fly   452 RFVARIN----QPADSVDATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYL 512
                |:|    |.|.::       ....|:..:|.|..|..:|||. |:...:|::|.:..:|.:
  Fly   817 ----RVNKTNWQTAPAI-------VNAYYSRNKNQIMFPAGILQPP-FYHRHFPKSLNFGGIGVV 869

  Fly   513 LAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEY--QYGGSKLPESKDQSE 575
            :.||:.|||||.||.:|.:||:..||...|...|:||.:|..|||..|  :..|..|.....|.|
  Fly   870 IGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGE 934

  Fly   576 NIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQ 640
            ||||:|||:.|:.||:.||.:...|| ..|.:.||.....|||||.:.|:.|.    ..:|...:
  Fly   935 NIADNGGLRQAFHAYQRWLKEHPSEV-SDEILPGLNMTGPQLFFLNFGQVWCG----AMRPEAIR 994

  Fly   641 SDR----HAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            :..    |:|.::||||.|||..:|...|||...:||:|:.||:::
  Fly   995 NKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	201/805 (25%)
Nep4	NP_650904.3	M13	274..1038	CDD:341056	202/806 (25%)