DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and Nep4

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	209/826 - (25%)
Similarity:	320/826 - (38%)	Gaps:	230/826 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IVQAKVAEMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRRLQRLLRA 106
            :.|||.  ||..|..:|.||.|||.:|||||.|.:|.. ......|.|:::.:..|..|:.||..
  Fly   260 MTQAKT--MKRYMDNKVDPCVDFYKYACGNWERLHPIP-KDKAGFDTFEMLRESLDLVLRNLLEK 321

  Fly   107 N-------------------------------DLQSEL-EKKMQRFYMS-CNLVHRDDVHYK--- 135
            |                               |..:|| .::::|..:| ..|::|..|.||
  Fly   322 NTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYT 386

  Fly   136 ----------------------------------------------------------------- 135

  Fly   387 NGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRS 451

  Fly   136 ------LA------LENVIREYGTLPALVGAQWNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDI 188
                  ||      |..:|||.|..|.| .:||:.|:|: |:.:|....:|...|:|...:..||
  Fly   452 CVNSAVLAKRGLEPLHTLIRELGGWPVL-ESQWSESNFN-WQVLAATLRRYNNDILIVQWVGADI 514

  Fly   189 RNTSVN-------------RVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQ 240
            :|:..|             |.|..||............|.||...|      |.|.:.|:..|.:
  Fly   515 KNSEENIVQFDQTGLGLPTREYFLQPSNAKYLQAYQRYMAEVMHKM------GASKADAQRVASE 573

  Fly   241 LTELERTFSSGGSGAATLQESLSLY---TVADLQ--------EKYSDHLNFTEFLGLILGEENIP 294
            |...|...:...:.|........||   |:..||        ..|...|...|    :||.|.:
  Fly   574 LVAFETQLAGITAPAEQRLNVTKLYKRMTLDQLQAVVPEIKWRAYLQSLQDRE----VLGTEEV- 633

  Fly   295 KSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDFL--VDAQPKDM---------------V 342
               .||..||:.|.:..:..|...|.:||::|:.:...:  ||.:..|:               .
  Fly   634 ---VIYAVEYMSKLVTLLDETDPRTVSNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQ 695

  Fly   343 KW--CTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLA 405
            :|  |........|.........||.:.:.:.:..::...::..||..|  ...||:.:.|:.||
  Fly   696 RWKVCIAQVNTNMGMAVGSMFVSRYFDNNSKRDTLRMTHDLQQAFRDIL--KTTDWLDDTTKQLA 758

  Fly   406 IEKLERMHLNI------------NS-------YDEENFENVYGEVFIDRLNYVSNVQQLLIAKGI 451
            .||:..|.|.|            ||       |.|:.|||.     ::.|.:.:..:|..:.:
  Fly   759 EEKVNAMSLKIGYPDFILNPSELNSKYAGIEIYPEKYFENT-----LNVLLHTAKTEQAKLHE-- 816

  Fly   452 RFVARIN----QPADSVDATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYL 512
                |:|    |.|.::       ....|:..:|.|..|..:|||. |:...:|::|.:..:|.:
  Fly   817 ----RVNKTNWQTAPAI-------VNAYYSRNKNQIMFPAGILQPP-FYHRHFPKSLNFGGIGVV 869

  Fly   513 LAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEY--QYGGSKLPESKDQSE 575
            :.||:.|||||.||.:|.:||:..||...|...|:||.:|..|||..|  :..|..|.....|.|
  Fly   870 IGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSNYTVEEVGIVLNGESTQGE 934

  Fly   576 NIADSGGLKLAYAAYELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQFLFQPWVSQ 640
            ||||:|||:.|:.||:.||.:...|| ..|.:.||.....|||||.:.|:.|.    ..:|...:
  Fly   935 NIADNGGLRQAFHAYQRWLKEHPSEV-SDEILPGLNMTGPQLFFLNFGQVWCG----AMRPEAIR 994

  Fly   641 SDR----HAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            :..    |:|.::||||.|||..:|...|||...:||:|:.||:::
  Fly   995 NKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	204/812 (25%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	201/805 (25%)
Nep4	NP_650904.3	M13	274..1038	CDD:189000	202/806 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850