DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and Nepl6

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_609023.3	Gene:	Nepl6 / 33893	FlyBaseID:	FBgn0259716	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	165/744 - (22%)
Similarity:	301/744 - (40%)	Gaps:	157/744 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LWLCLLVAIVPAMAKPSDAGDPFADDLTSDYAKKII--VQAKVAEMKTMMKPEVSPCDDFYTHAC 69
            :||...:.|||..|.|:      ..::.:|...:::  :.:.|||       :.|.|..::.:||
  Fly     1 MWLIACLFIVPICAAPT------TQNVEADPNSRLMNNILSYVAE-------DSSACGTYFQYAC 52

  Fly    70 GNW---HRHNP----AQLLGDVMTDNFKLI---------SKGFDRRLQRLLRANDLQSELEKKMQ 118
            |.:   ||.:|    .|:|...:..|...:         |.||:            :|.:|.|:.
  Fly    53 GKYAVRHRDDPFTEIIQMLDHKVNGNLVQLMHELHQRSQSPGFN------------ESSVEAKVL 105

  Fly   119 RFYMSCNLVHRDDVHYKLALENVIR-----EYGTLPALV--GAQWNSSDFSWWRTVAQIQHKYG- 175
            .||.:|    |:.......:|:.:|     :..|.|..:  |..|..:.|.|.:::..: ::||
  Fly   106 HFYRTC----REAPPSTRKMEHYLRLAPPGQALTWPQFMPRGEPWPKAQFKWMKSLGHL-YRYGF 165

  Fly   176 KQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQ 240
            ..:::.:.::....|::..|:.||.|..:.....|...:..:.|    .|..|:.:   |.....
  Fly   166 TNVLVNVLVLRSSENSNRFRLDISMPSLEGDAQHLGGFLSTLAT----LQIIGVPT---KSILPL 223

  Fly   241 LTELERTFSSGGSGAATLQESLSLYTVAD----------LQEKYSDHLNFTEFLGLILGEENIPK 295
            :.::.|           |:.::.:.|..|          .|.:|.....:..|:..|:|..  ..
  Fly   224 VRKIRR-----------LESAIRVLTEVDDDDESETWTLRQWEYKTGYAWQGFVESIVGHS--VS 275

  Fly   296 SLYI---YDEEYLDKALLTMRSTPLATQANYVLWK----LLEDFLVDAQPKDMVKWCTESTKKYF 353
            ..|:   .:.:|.......|.||.....|||::.:    |::||:...:..|    |....::..
  Fly   276 HHYVMQAQNAKYFTGLKRLMDSTDAEVVANYIMTRFVLYLIDDFIDSNEHID----CVTDMRRNM 336

  Fly   354 GKLAEHAVYK-RYRNP----DVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMH 413
             .||.:.:|| |:.:|    ....||.|:::|::..|..::..::|. :::...::...|.:.:.
  Fly   337 -NLASNLLYKERFLDPATLQQYTQEVTKVFEQLRRQFLLQINENRLG-LTSEQNSMVATKAQHVV 399

  Fly   414 LNINSY----DEENFENVYGE--VF-IDRLNYVSNVQQLLIAKGIRFVARINQPADS-------V 464
            |||.:.    |..:|.:.:.|  || :...:|......||..:..:.|.::||.|.:       .
  Fly   400 LNIGNLPRGRDHRSFVSRHYEDLVFPLPDFDYAREHLNLLEFRTRKQVLQLNQSAPTPDEFFYLS 464

  Fly   465 DATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYD 529
            |....:...|.|.::.|.|.:|..|||..:|..|.: :..||:.||::||||::|..|..|..||
  Fly   465 DPKTAMSSGPYYLMRLNIIVVPHGLLQEPFFAADSH-DIFKYSLLGFVLAHELMHSVDTVGLYYD 528

  Fly   530 ASGN---LAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSENIADSGGLKLAYAAYE 591
            ..||   :.|  .:.|...|....:|......:|            ..|.|||..||.|||:.|
  Fly   529 RYGNIHEIGP--QISSSPRFVAGLQCLNRNSTQY------------LDERIADIAGLDLAYSTY- 578

  Fly   592 LWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLC---DDVQFLFQPWVSQSDRHAPSKYRVIG 653
                .|:...:.......:|  .:|:|||..||..|   |.:.|:         .|...:.|:..
  Fly   579 ----FQNSSQMSLTDFTTIP--PQQIFFLNLAQFFCGDGDPINFV---------GHDNDETRLQQ 628

  Fly   654 PLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            .|:.|..|...|.|...: ..|| ||.::
  Fly   629 MLNGFAPFHEAFGCPAKS-NQPE-KCQLW 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	154/693 (22%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	152/686 (22%)
Nepl6	NP_609023.3	M13	42..653	CDD:189000	153/686 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840