DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and Nepl5

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	184/747 - (24%)
Similarity:	312/747 - (41%)	Gaps:	135/747 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRVLWLCLLVA--IVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAE-MKTMMKPEVSPCDDFY 65
            |.|.||...:|  ..|...:.::|...              ||..:|| :::.|..:..||::||
  Fly     5 SLVAWLIFSLAWRTTPTACRQTNAPQS--------------VQEMLAEQLQSYMDTKARPCENFY 55

  Fly    66 THACGNWHRHNPAQ--------------LLGDVM-TDNFKLISKGFDRRLQRLLRAN-----DLQ 110
            .:|||||......|              ..|.:: ||...||....:|:|:.|||..     :..
  Fly    56 QYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESD 120

  Fly   111 SELEKKMQRFYMSCNLVHRDDVHYKLALENVIREYGTLP-------ALVGAQWNSSDFSWWRTVA 168
            |.:.::|:.:|.||.         :|...|:.:....||       ..||..|....|.|..|:.
  Fly   121 SSILEQMRLYYRSCK---------RLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLG 176

  Fly   169 QIQHKYGKQIIIGLEIM---HDIRNTSVNRVYISQPDFKTINTRLTNLMEE---VRTSMDLQQYF 227
            :::......:::..|::   .|.||.|   :|:::|     :.:.|..|.|   :...:|:
  Fly   177 RLRLHGLNGVLLREEVLPRWDDSRNYS---IYVNKP-----SRQETQPMGEGAMIELLLDI---- 229

  Fly   228 GLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQ----EKYSDHLNFTEFLGLIL 288
            |.:...|...|.|:.:.||...       .|||........::|    :.|...|.:..|:..:.
  Fly   230 GQTKRTANALARQVDDFERKLH-------RLQELEDDEGPREMQLGYLDSYLPQLRWLSFMRQVR 287

  Fly   289 --GEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDFLVDAQPKDMVKW-CTESTK 350
              .|.::..:|.|.:..||......|.|....|..:|::.|.|. ||....|.|:.:. |..:.:
  Fly   288 IDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLA-FLKQQGPADISRGECVAALR 351

  Fly   351 KYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLN 415
            :.....:...|.:::.:|:.||.|..::.::|..|.|.|..:::. :|.....:..:||..:.|.
  Fly   352 RAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMR-LSPPLVHILQQKLRAVRLQ 415

  Fly   416 INSYDEENFENV--------------YGEVFIDRLNYVSNVQQLLIAKGIRFV----ARINQPAD 462
            :..:..|..|:|              ||...:.....|.....||......|.    :.::..::
  Fly   416 MGFFQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSE 480

  Fly   463 SVDATELLGFTPAYNIQENNITIPVALLQ-PRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGR 526
            |.:|:   ..:|.|....|.:.:|..||| |  .|........::|.:|::||||:.||||..|.
  Fly   481 SWEAS---NSSPLYVRPRNLVLVPHGLLQLP--IWHRNISALQQHAVMGFVLAHELAHGFDMLGM 540

  Fly   527 QYDASGN-LAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSKLPESKDQSENIADSGGLKLAYAAY 590
            .|||.|| :.|..::.:..:|.:..:|.|.|    ...|||..:     |.:||...|:|   ||
  Fly   541 DYDAMGNIMGPVEEIGASRQFRQGLQCLQQQ----MATGSKWID-----EKLADFVALRL---AY 593

  Fly   591 ELWLGQQSEEVLQRETMEGL--PFNSRQLFFLGYAQLLCDDVQFLFQPWVSQSD---RHAPSKYR 650
            |.:.|.:.    :||..:.|  .|:.|||||:.:||..|.....|...  |||:   :||..:.|
  Fly   594 ETFFGVRD----KREPRDPLLPQFSQRQLFFITFAQFFCGRTPVLSPR--SQSEAHLKHAADELR 652

  Fly   651 VIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
            |:..|:||:||...|.|.:.|.|....:|.|:
  Fly   653 VMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	172/692 (25%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	170/685 (25%)
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	172/694 (25%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	170/686 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850