Protein Alignment Nepl18 and Nepl4

DIOPT Version :10

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 766
• Identity: 162/766 - (21%)
• Similarity: 280/766 - (36%)
• Gaps: 208/766 - (27%)

  Fly     7 LWLCLLV-------AIVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDF 64
            ||..||:       :.||..|...:...|:..:..|     .|.|..:..:.:.:..|.:||:||
  Fly     5 LWTALLLLGSATCGSSVPVKANDPEQSCPYLGECNS-----TINQQHIDTLMSYVDSEKNPCEDF 64

  Fly    65 YTHACGNWH----RHNPAQLLGDVMTDNFKLISKGFDRRLQRLLR---ANDLQSELEKKMQRFYM 122
            |.:|||.|.    .|..|.::.:      ..|::.::....:|||   |.:....:..|:...|.
  Fly    65 YAYACGKWRAKHGSHTTATMISE------SQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQ 123

  Fly   123 SCNLVHRDDVHY--------KLALENVIREYGTLPAL-----------VGAQWN----------- 157
            ||..:.:.|:..        .||..|.......|.||           |..:|.
  Fly   124 SCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHHMIFLLP 188

  Fly   158 -----------------SSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKT 205
                             |.|.|.|..:.|:|.::              |:...|.|.:::| ...
  Fly   189 HNRHLNLSLTQDIYDALSQDGSSWPPLHQLQEQF--------------RSLEQNLVRLAKP-HSA 238

  Fly   206 INTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQL-TELERTFSSGGSGAATLQESLSLYTVAD 269
            .:|.....::::||.:.     ||      |..|.| |:|.|:....           .::.|.|
  Fly   239 DDTFRNYSLDQIRTEVP-----GL------HWDEALRTQLGRSVPGN-----------HVFQVDD 281

  Fly   270 LQ--EKYSDHLNFTEFLGLILGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDF 332
            |.  |...::||..:  .|:|...::.:.|         ..||.:...||||      |:..:
  Fly   282 LDAIEGLVEYLNTVD--TLLLNRYSLARFL---------SHLLELPHNPLAT------WESGQ-- 327

  Fly   333 LVDAQPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWI 397
              .::.::.::....|.......:.|.:.|.|.|:.| |..:|.::.|::.....|:..:..:..
  Fly   328 --RSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHAD-ELVIHSVFQQLQSQLELRVQHNAFNLS 389

  Fly   398 SNATRTLAIEKLERMHLNINS----------YDEENFENVYGEVFIDRLN----YVSNVQQLLIA 448
            .:..::|. .|:.:|.:|:.:          :|.:...:|..:.:.:.||    |.:.|..|..:
  Fly   390 QDLVKSLQ-AKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGRDFYENHLNSLLYYYTLVADLESS 453

  Fly   449 -----KGIRFVARINQP--ADSVDATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKY 506
                 :.|.:...::.|  .|::||      ||.:....|.|.:|.:.::..:|..:.:| ||.|
  Fly   454 SDQEERDIWYSFNMHTPEFPDNIDA------TPYFYCLGNIIFVPYSYVKRPFFDANFWP-ALLY 511

  Fly   507 ATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSK--LPE 569
            ..|...|.||::|.||.|...|||.|||..:.|.....|.               |.|:.  |..
  Fly   512 GDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVEL---------------YNGAVGCLNS 561

  Fly   570 SKDQ-SENIADSGGLKLAYAAY-ELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQF 632
            |... :|..:|..|.:||...| ..||           |..|   |.| |:||.:|...|.|
  Fly   562 SAVMLNERTSDVSGSRLAMQTYGGDWL-----------TRSG---NGR-LYFLQFAHFFCGD--- 608

  Fly   633 LFQPWVSQSDR-HAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682
                   :.|: |.....|:...|....:|..||.|...:.|....:|..:
  Fly   609 -------EGDQYHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	M13	58..679	CDD:341056	149/703 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	149/702 (21%)