DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl18 and goe

DIOPT Version :9

Sequence 1:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001285350.1	Gene:	goe / 32660	FlyBaseID:	FBgn0027528	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	158/810 - (19%)
Similarity:	269/810 - (33%)	Gaps:	242/810 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLWLCLLVAIVPAMAKPSDAGDPF-------ADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDD 63
            :|.:.||:|..|.:        ||       .|....:.::::::.|..::         |||.:
  Fly   141 LLIIILLLAFWPEV--------PFYLRAPLCLDKECVESSRQLLLWANTSK---------SPCHE 188

  Fly    64 FYTHACGNWHRHNPAQLLGDVMTDNFKLISKG---FD-----RRLQRLLR-----ANDLQSELEK 115
            .|..||||:        ..|.....:.:|.:|   ::     :.|..|.|     .|..:..:|.
  Fly   189 TYEWACGNF--------ASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGSVES 245

  Fly   116 KMQRFYMSCNLV-----HRDDVHYKLALENVIREYGTLPALVGAQW----NSSDFSWW---RTVA 168
            .:...|.||...     .:.|:..|.|:..|   ||         |    :|:....|   |.:.
  Fly   246 TVSSLYRSCRETDVLDKSQSDLLLKRAINAV---YG---------WQAFRDSNRLQSWEYKRVLV 298

  Fly   169 QIQHKYG----KQIII--GLEIMHDIRNTSVNRVYISQPD---------------FKTINTRLTN 212
            .:|.|:|    .::.:  |....||...| ::...:..||               :|.:......
  Fly   299 VLQAKHGIFPYYRVTVENGFSNPHDYVIT-LDEGELGLPDKYFYGNDADEEVVRGYKLLLRDFAI 362

  Fly   213 LMEEVRTSMDL--QQYFGLSSSVAKHTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYS 275
            .|..|....||  ...|.....:..|..:...:..|..:             .|..:|||:.| :
  Fly   363 NMGIVSREADLFADDIFHYERRIVNHIEDAKADANRPIN-------------KLMRLADLKIK-A 413

  Fly   276 DHLNFTEFLGLILGEENIPKSLYIYDEEYL--DKALLTMRSTPLATQ-----ANYVLWKLLEDFL 333
            ..|...|.|..|     .||:....|.|.|  |..::...|..|:|.     .|:::|.|....|
  Fly   414 PSLPILESLQAI-----FPKTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKML 473

  Fly   334 VDAQPKDMVKWCTESTKKYFGKLAE---HAVYKR---YRNPDVESEVHKIW-------------- 378
                         ....|.:..|||   ||:|.|   |....:.|:|.:.|
  Fly   474 -------------PHLSKEYRTLAETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPR 525

  Fly   379 --------------------DQIKGIF--RQRLLGDKLD---WISNATRTLAIEKLERMHLNINS 418
                                :.:|.:|  .:..|.|.|:   |:..|.|....:||..|.|....
  Fly   526 QQFETMTSKSRGLNKTQGNEELLKLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGI 590

  Fly   419 YDE-----ENFENVYGEVFIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATELLGFTP---- 474
            .||     ......|.|:.::.:.:|.:::.:...:..:...::. |...:|......:|.
  Fly   591 PDEVLQQPTYLAQYYNELILNNVFFVEHLEWIWTFRRSQMEKKLG-PLAILDVIVSEMYTRDNPQ 654

  Fly   475 --AYNIQENNITIPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDAS----GN 533
              ||:.:.|.:.:...|:...|: ..:||.|:.:|.:|..:...::..|.....|::..    .:
  Fly   655 AIAYSNKLNMLLVSKVLISSNYY-DYRYPVAVNFARIGTDILEALIDNFSTFLLQFNTQSTDISD 718

  Fly   534 LAPWWDLKSRYEFEERRKCFQA-----QYHEYQYGGSKLPESKDQSENIADSGGLKLAYA----- 588
            .||    :.||. :....|..|     ..||.    ::|..:..:|.::..|.....|.|
  Fly   719 AAP----EIRYA-QPDVNCLAAGQPPRLVHEL----NELSSNALKSFHVTLSAARTAARALSNFV 774

  Fly   589 -AYELWLGQQSEEVLQRETMEGL------------PFNSRQLFFLGYAQLLCDDVQFLFQPWVSQ 640
             |.:.....|...:.|..|.|.|            .||..:||.|.|.|..|
  Fly   775 NAIDAGSAIQGSGIDQANTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHC------------- 826

  Fly   641 SDRHAPSKYRVIGPL--SNFQEFPWVFNCS 668
            |...|...|..|.||  |...| .::||.:
  Fly   827 STTIADKDYARIKPLVESQLAE-SYLFNAT 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	149/755 (20%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	149/751 (20%)
goe	NP_001285350.1	GluZincin	184..>694	CDD:301352	110/564 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840