Protein Alignment Nepl18 and Nep1

DIOPT Version :9

• Sequence 1: NP_651643.1
• Gene: Nepl18 / 43410
• FlyBaseID: FBgn0039611
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_001284925.1
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Alignment Length: 718
• Identity: 193/718 - (26%)
• Similarity: 325/718 - (45%)
• Gaps: 134/718 - (18%)

  Fly    48 AEMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTD-----NFKLISKGFDRRLQRLLRA- 106
            |.:.:.|.....||:||:.:|||.|::.:|      :..|     .|:::|   |:: |.:|||
  Fly   183 ASLLSAMDLNSDPCEDFFQYACGTWNKMHP------IPEDRSSISTFEVLS---DQQ-QVILRAV 237

  Fly   107 -----NDLQSELEKKMQRFYMSCNLVHRDDVHY--KLA---LENVIREYGTLPALVGAQWN-SSD 160
                 ::..::...|.:.|:.||.     |:..  |:.   |:.|::..|..| ::...|: .:|
  Fly   238 LEEPIDERDNKATIKAKTFFKSCM-----DIPQIRKIGTGRLKQVLQSLGGWP-VIERNWSPPAD 296

  Fly   161 FSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKTINTRLTNLMEEVRTSMDLQQ 225
            .|..|.:.|::..|.:.::|.|.:..|.:|:|||   |.|             |::::.::..:.
  Fly   297 LSVERLMGQLRLNYSEPVMIELYVGADDKNSSVN---ILQ-------------MDQLQYALPSRD 345

  Fly   226 YFGLSSSVAKHTA--EQLTELERTFSSGGSGAATLQESLSLY----------------------- 265
            |:...||.....|  ..:|::.....:..:.||...|.:.|:
  Fly   346 YYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRK 410

  Fly   266 -TVADLQEKYSDHLNFTEFLGLILG-----EENIPKSLYIYDEEYLDKALLTMRSTPLATQANYV 324
             .:.:|||...: :.:.|:|...||     :|:.|  |..|...||.:....:..|......||:
  Fly   411 MLLPELQELVPE-VQWQEYLQAALGPGIPLQEDEP--LVTYGLHYLTEMGKILAHTDRRVVHNYM 472

  Fly   325 LWKL---LEDFLVDAQPKDMV--------------KW--CTESTKKYFGKLAEHAVYKRYR-NPD 369
            ||:|   |...::|...::.|              :|  |.|.|.|..| :|..|::.|.. |.:
  Fly   473 LWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLG-VAVGALFIRDNFNQE 536

  Fly   370 VESEVHKIWDQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYDE-----ENFENVYG 429
            .:....::...|:..|.: ||.:. ||:.:.||.:|.||.:.|:..| .|.|     ...|..|.
  Fly   537 SKEVALEMIHTIRAAFNE-LLAEN-DWMDDETRAVAKEKADSMNERI-GYPELLTNATELEQEYV 598

  Fly   430 EVFIDRLNYVSNVQQLLIAKGIRFVARINQPADSVD-ATELLGFTPAYNIQENNITIPVALLQPR 493
            .:.|...|:::||..:|..:..:.:..:.||.|... .||.......||..:|:|..|..:|||
  Fly   599 NLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQP- 662

  Fly   494 YFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYH 558
            .|:...:|::|.|..:|.::.||:.|||||.|||:|..||:..||:..:...|.||.:|...||.
  Fly   663 LFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYS 727

  Fly   559 EYQYGGSKLPE-------SKDQSENIADSGGLKLAYAAYELWLGQQSEEVL--QRETMEGLPFNS 614
            .|     |:.|       ...|.|||||:||||.|:.||:.|      |.|  :.:.:.||....
  Fly   728 RY-----KINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKW------ETLHGREQQLPGLNMTH 781

  Fly   615 RQLFFLGYAQLLCDDVQFLFQPWVSQSDRHAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKC 679
            .|||||.|||:.|..::........:|..|:|...||:|||||.::|...:.|...:.|:|..||
  Fly   782 DQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKC 846

  Fly   680 AIY 682
            :::
  Fly   847 SVW 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	192/710 (27%)
		M13	58..679	CDD:189000	189/703 (27%)
Nep1	NP_001284925.1	M13	194..847	CDD:189000	190/703 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800